Characterising the allergic profile of children with cystic fibrosis

Background: Cystic fibrosis (CF) is a genetic condition that affects multiple organ systems. Allergic bronchopulmonary aspergillosis (ABPA) is a well-recognised problem but other allergic conditions are less well documented in CF. Objective: To characterise the allergic profile of a cohort of children with CF, with a focus on those with ABPA. Methods: A cohort of children with CF were interviewed and retrospective data were collected regarding their allergic histories and other relevant clinical features. Results: The cohort included 37 children with median age of 9 years (interquartile range: 6-12). There was a history of >= 1 allergic condition(s) in 28/37 children (76%). The most common allergic condition was allergic rhinitis (AR) in 21/37 (57%) and 16 of these 21 children (76%) had another allergic condition. All children with ABPA (8) had another allergic condition. In some children ABPA exacerbations appeared to be seasonal, suggesting possible cross-sensitisation between Aspergillus fumigatus and aeroallergens associated with seasonal AR. Allergic conditions were also common in children with Pseudomonas aeruginosa infection.

Automated summary

A study of 37 children with CF found that 76% of them had one or more allergic conditions, with allergic rhinitis being the most common. All children with ABPA had another allergic condition, with seasonal exacerbations possibly related to cross-sensitisation between Aspergillus and aeroallergens associated with seasonal AR. Allergic conditions were also common in children with Pseudomonas aeruginosa infection.