Journal
IMMUNITY INFLAMMATION AND DISEASE
Volume 10, Issue 1, Pages 111-116Publisher
WILEY
DOI: 10.1002/iid3.541
Keywords
HLA; MERS; MERS-CoV; Middle East respiratory syndrome coronavirus
Categories
Funding
- National Research Foundation of Korea (NRF) - Ministry of Education [2019R1I1A1A01064049]
- National Medical Center of the Republic of Korea [NMC2018-MS-01]
- Korean Health Technology R&D Project of the Ministry for Health & Welfare of the Republic of Korea [HI14C3417]
- National Research Foundation of Korea [2019R1I1A1A01064049] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The study found that HLA-DQB1*03:02 is significantly associated with moderate/mild cases of MERS-CoV, while other alleles showed no statistical significance. Future treatment strategies may benefit from targeting the HLA gene based on this research on MERS-CoV.
Introduction: Middle East Respiratory Syndrome (MERS) caused by MERS-coronavirus (CoV) is a lower respiratory tract disease characterized by a high mortality rate. MERS-CoV spread from Saudi Arabia to other countries, including South Korea. Dysfunction of the human leukocyte antigen (HLA) system has many effects due to genetic complexity and its role in the adaptive immune response. We investigated the association of HLA class I and II alleles with MERS-CoV in 32 patients with MERS. Methods: HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1 were genotyped by polymerase chain reaction sequence-based typing. Results: HLA-DQB1*03:02 are significantly associated with moderate/mild cases of MERS-CoV. Other alleles are no statistical significance. Conclusions: Treatment strategies based on current research on the HLA gene and MERS-CoV will provide potential therapeutic targets.
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