4.4 Article

Opinion on the impact of non-monotonic dose responses on EFSA's human health risk assessments

Related references

Note: Only part of the references are listed.
Article Food Science & Technology

Statement on the derivation of Health-Based Guidance Values (HBGVs) for regulated products that are also nutrients

Simon More et al.

Summary: This Statement proposes a harmonised approach for establishing Health-Based Guidance Values (HBGVs) for regulated products that are also nutrients, outlining specific considerations and a decision tree for risk characterisation. It recommends involving relevant EFSA Panels and units for integrated hazard and risk characterisation of regulated products that are also nutrients.

EFSA JOURNAL (2021)

Review Toxicology

Quantitative adverse outcome pathway (qAOP) models for toxicity prediction

Nicoleta Spinu et al.

ARCHIVES OF TOXICOLOGY (2020)

Article Pharmacology & Pharmacy

Toxic Responses Induced at High Doses May Affect Benchmark Doses

Juerg A. Zarn et al.

DOSE-RESPONSE (2020)

Article Food Science & Technology

A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results

L. Camacho et al.

FOOD AND CHEMICAL TOXICOLOGY (2019)

Article Food Science & Technology

CLARITY-BPA Core Study: Analysis for non-monotonic dose-responses and biological relevance

Melissa A. Badding et al.

FOOD AND CHEMICAL TOXICOLOGY (2019)

Article Environmental Sciences

Adverse outcome pathway networks II: Network analytics

Daniel L. Villeneuve et al.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2018)

Article Environmental Sciences

Adverse outcome pathway networks I: Development and applications

Dries Knapen et al.

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY (2018)

Article Endocrinology & Metabolism

Haloperidol ameliorates androgen-induced behavioral deficits in developing male rats

Chunxiao Qi et al.

JOURNAL OF ENDOCRINOLOGY (2018)

Editorial Material Pharmacology & Pharmacy

Nonmonotonic Dose-Response Curves Occur in Dose Ranges That Are Relevant to Regulatory Decision-Making

Corinne E. Hill et al.

DOSE-RESPONSE (2018)

Article Public, Environmental & Occupational Health

Metabolomic Markers of Phthalate Exposure in Plasma and Urine of Pregnant Women

Michael Zhou et al.

FRONTIERS IN PUBLIC HEALTH (2018)

Review Endocrinology & Metabolism

Early-life exposure to EDCs: role in childhood obesity and neurodevelopment

Joseph M. Braun

NATURE REVIEWS ENDOCRINOLOGY (2017)

Article Food Science & Technology

Probabilistic assessment method of the non-monotonic dose-responses-Part II: Robustness assessment

Gregoire Chevillotte et al.

FOOD AND CHEMICAL TOXICOLOGY (2017)

Article Food Science & Technology

Probabilistic assessment method of the non-monotonic dose-responses-Part I: Methodological approach

Gregoire Chevillotte et al.

FOOD AND CHEMICAL TOXICOLOGY (2017)

Review Geriatrics & Gerontology

How does hormesis impact biology, toxicology, and medicine?

Edward J. Calabrese et al.

NPJ AGING AND MECHANISMS OF DISEASE (2017)

Review Environmental Sciences

Non-monotonic dose-response relationships and endocrine disruptors: a qualitative method of assessment

Fabien Lagarde et al.

ENVIRONMENTAL HEALTH (2015)

Article Biochemistry & Molecular Biology

Tanshinone IIA Exhibits Anticonvulsant Activity in Zebrafish and Mouse Seizure Models

Olivia Erin Buenafe et al.

ACS CHEMICAL NEUROSCIENCE (2013)

Article Toxicology

Acute effects of a low-dose atropine/scopolamine mixture as a food contaminant in human volunteers

Lucija Perharic et al.

JOURNAL OF APPLIED TOXICOLOGY (2013)

Review Endocrinology & Metabolism

Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses

Laura N. Vandenberg et al.

ENDOCRINE REVIEWS (2012)

Article Pharmacology & Pharmacy

Estrogen-Like Disruptive Effects of Dietary Exposure to Bisphenol A or 17α-Ethinyl Estradiol in CD1 Mice

Eric L. Kendig et al.

INTERNATIONAL JOURNAL OF TOXICOLOGY (2012)

Article Pharmacology & Pharmacy

Comparison of caffeine-induced locomotor activity between adolescent and adult rats

Marcelo T. Marin et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2011)

Article Biochemistry & Molecular Biology

Sex-specific serum biomarker patterns in adults with Asperger's syndrome

E. Schwarz et al.

MOLECULAR PSYCHIATRY (2011)

Article Biochemistry & Molecular Biology

Myricetin and quercetin are naturally occurring co-substrates of cyclooxygenases in vivo

Hyoung-Woo Bai et al.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2010)

Article Substance Abuse

Ethanol-Induced Social Facilitation in Adolescent Rats: Role of Endogenous Activity at Mu Opioid Receptors

Elena I. Varlinskaya et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2009)

Article Biochemistry & Molecular Biology

Biphasic activity of resveratrol on indomethacin-induced gastric ulcers

Anindya Dey et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)

Article Toxicology

The Effects of Triclosan on Puberty and Thyroid Hormones in Male Wistar Rats

Leah M. Zorrilla et al.

TOXICOLOGICAL SCIENCES (2009)

Article Pharmacology & Pharmacy

Toxicological awakenings: the rebirth of hormesis as a central pillar of toxicology

EJ Calabrese

TOXICOLOGY AND APPLIED PHARMACOLOGY (2005)

Review Biochemistry & Molecular Biology

Caffeine as a psychomotor stimulant: mechanism of action

G Fisone et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2004)

Article Behavioral Sciences

The effect of cyanamide and 4-methylpyrazole on the ethanol-induced locomotor activity in mice

MD Escarabajal et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2002)

Article Toxicology

Hormesis: A generalizable and unifying hypothesis

EJ Calabrese et al.

CRITICAL REVIEWS IN TOXICOLOGY (2001)