Visible-Light-Mediated Synthesis of α-Halomethyl Ketones from Terminal Alkynes

A visible-light-assisted approach for the synthesis of alpha-halomethyl ketones from terminal alkynes has been developed. The reaction introduces halogen at the alpha-position of terminal alkynes using N-halosuccinimides as the halogen source. It relies on the photodegradation of N-halosuccinimides obviating the requirement for a photocatalyst. The procedure enables the synthesis of a diverse range of alpha-haloketones from different aromatic bromo- and iodoalkynes.

Automated summary

This approach utilizes N-halosuccinimides as the halogen source to introduce halogen at the alpha-position of terminal alkynes, without the need for a photocatalyst. It allows for the synthesis of a diverse range of alpha-haloketones from different aromatic bromo- and iodoalkynes.