Journal
LIFE-BASEL
Volume 12, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/life12020172
Keywords
GPCR; prokineticin receptors; prokineticins; transcriptional and post-transcriptional regulation; post-translational regulation; alternative splicing; binding; oligomerization; inhibitors
Categories
Ask authors/readers for more resources
This review summarizes the major cellular and biochemical mechanisms of prokineticins pathway regulation and discusses the potential for therapeutic intervention.
Prokineticins are a new class of chemokine-like peptides that bind their G protein-coupled receptors, PKR1 and PKR2, and promote chemotaxis and the production of pro-inflammatory cytokines following tissue injury or infection. This review summarizes the major cellular and biochemical mechanisms of prokineticins pathway regulation that, like other chemokines, include: genetic polymorphisms; mRNA splice modulation; expression regulation at transcriptional and post-transcriptional levels; prokineticins interactions with cell-surface glycosaminoglycans; PKRs degradation, localization, post-translational modifications and oligomerization; alternative signaling responses; binding to pharmacological inhibitors. Understanding these mechanisms, which together exert substantial biochemical control and greatly enhance the complexity of the prokineticin-receptor network, leads to novel opportunities for therapeutic intervention. In this way, besides targeting prokineticins or their receptors directly, it could be possible to indirectly influence their activity by modulating their expression and localization or blocking the downstream signaling pathways.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available