Journal
BIOSENSORS-BASEL
Volume 11, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/bios11100360
Keywords
immunosensors; electrochemical immunosensors; biosensors; voltammetric immunosensors; amperometric immunosensors; impedimetric immunosensors; eletrochemiluminescent immunosensors
Funding
- National Research Foundation of Korea (NRF) - Korean Government (MSIP) [2021R1I1A305570011]
- Technology Innovation Program - Ministry of Trade, Industry and Energy (MOTIE, Korea), Republic of Korea [20008414]
- Korea Evaluation Institute of Industrial Technology (KEIT) [20008414] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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This paper reviews the recent progress in electrochemical immunosensors, focusing on the immobilization methods using antibodies for voltammetric, amperometric, impedimetric, and electrochemiluminescent immunosensors. The use of antibodies as molecular recognition molecules and the introduction of electrochemistry for quantitative signals are highlighted in the detection of biomarkers.
Biosensors used for medical diagnosis work by analyzing physiological fluids. Antibodies have been frequently used as molecular recognition molecules for the specific binding of target analytes from complex biological solutions. Electrochemistry has been introduced for the measurement of quantitative signals from transducer-bound analytes for many reasons, including good sensitivity. Recently, numerous electrochemical immunosensors have been developed and various strategies have been proposed to detect biomarkers. In this paper, the recent progress in electrochemical immunosensors is reviewed. In particular, we focused on the immobilization methods using antibodies for voltammetric, amperometric, impedimetric, and electrochemiluminescent immunosensors.
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