Journal
WORLD JOURNAL OF DIABETES
Volume 12, Issue 11, Pages -Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4239/wjd.v12.i11.1818
Keywords
Organophosphate; Pesticide; New-onset diabetes mellitus; Mechanism; Reactive oxygen species
Categories
Funding
- Chang Gung Memorial Hospital, Linkou, Taiwan [CORPG3K0191, CMRPG3J1051-3]
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Organophosphate is a commonly used pesticide in the agricultural sector, which can lead to hyperglycemia and new-onset diabetes mellitus. Currently, there is no preventive strategy for organophosphate-mediated new-onset diabetes mellitus, but reducing reactive oxygen species levels may help to reduce the risk of developing hyperglycemia.
Organophosphate is a commonly used pesticide in the agricultural sector. The main action of organophosphate focuses on acetylcholinesterase inhibition, and it therefore contributes to acute cholinergic crisis, intermediate syndrome and delayed neurotoxicity. From sporadic case series to epidemiologic studies, organophosphate has been linked to hyperglycemia and the occurrence of new-onset diabetes mellitus. Organophosphate-mediated direct damage to pancreatic beta cells, insulin resistance related to systemic inflammation and excessive hepatic gluconeogenesis and polymorphisms of the enzyme governing organophosphate elimination are all possible contributors to the development of new-onset diabetes mellitus. To date, a preventive strategy for organophosphate-mediated new-onset diabetes mellitus is still lacking. However, lowering reactive oxygen species levels may be a practical method to reduce the risk of developing hyperglycemia.
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