Journal
FRONTIERS IN NUTRITION
Volume 8, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnut.2021.806623
Keywords
zein; glycosylated lactoferrin; nanoparticles; bioaccessibility; 7; 8-dihydroxyflavone
Categories
Funding
- Zhejiang Province Public Welfare Technology Application Research Project-National Cooperation Project [LGJ21C20001]
- Fund of Key Laboratory of Aquatic Product Processing, Ministry of Agriculture and Rural Affairs, China [NYJG202104]
- Fund of Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety [GDPKLAPPS2101]
- Guangxi Natural Science Foundation Program [2018GXNSFBA294015]
- Zhejiang Province Xinmiao Talents Program [2021R403035]
- National College Students Innovation and Entrepreneurship Training Program [2021052, 2021011]
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In this study, glycosylated lactoferrin was successfully used to establish stable zein/glycosylated lactoferrin nanoparticles for encapsulating 7,8-dihydroxyflavone. The encapsulated 7,8-dihydroxyflavone exhibited an amorphous state inside the nanoparticles and showed good water redispersibility and bioaccessibility. This research provides a theoretical reference for the application of zein-based delivery systems.
In this work, the lactoferrin (LF) was glycosylated by dextran (molecular weight 10, 40, and 70 kDa, LF 10K, LF 40K, and LF 70K) via Maillard reaction as a stabilizer to establish zein/glycosylated LF nanoparticles and encapsulate 7,8-dihydroxyflavone (7,8-DHF). Three zein/glycosylated LF nanoparticles (79.27-87.24 nm) with low turbidity (<0.220) and polydispersity index (PDI) (<0.230) were successfully established by hydrophobic interactions and hydrogen bonding. Compared with zein/LF nanoparticles, zein/glycosylated LF nanoparticles further increased stability to ionic strength (0-500 mM NaCl) at low pH conditions. Zein/glycosylated LF nanoparticles had nanoscale spherical shape and glycosylated LF changed surface morphology of zein nanoparticles. Besides, encapsulated 7,8-DHF exhibited an amorphous state inside zein/glycosylated LF nanoparticles. Most importantly, zein/glycosylated LF nanoparticles had good water redispersibility, high encapsulation efficiency (above 98.50%), favorable storage stability, and bioaccessibility for 7,8-DHF, particularly LF 40K. Collectively, the above research provides a theoretical reference for the application of zein-based delivery systems.
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