Journal
SURFACES AND INTERFACES
Volume 28, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.surfin.2021.101674
Keywords
Polyurethane; Chitosan; Unfractionated heparin; Layer-by-layer method; Blood recalcification time; Thromboresistance; Hemolysis of red blood cells
Categories
Funding
- Russian Foundation for Basic Research [20-33-70168, 18-015-00402_a]
Ask authors/readers for more resources
The surface of polyurethane plates was activated and modified by applying polyelectrolytes, resulting in improved hydrophilic properties and increased thromboresistance. The modified plates showed enhanced clotting and recalcification time in vitro, as well as minimal hemolysis.
The surface of polyurethane plates was activated using hexamethylenediisocyanate in the presence of a dibutyltin dilaurate catalyst. The presence of isocyanate groups was confirmed by FTIR spectroscopy. Polyelectrolytes chitosan and heparin were applied layer-by-layer to the activated polyurethane plates surface. The morphology of the plates surface at all stages of modification was studied using atomic force microscopy and scanning electron microscopy. An increase in the hydrophilic properties of the surfaces of modified polyurethane plates is confirmed by a decrease in the value of water contact angle. Modification of the polyurethane plates resulted in increased clotting time and recalcification time in vitro in the human blood. Thromboresistance of polyurethane plates during incubation in in vitro experiments for 20, 40, 120, 240 min reached 83,94 +/- 8,12% -86,22 +/- 5,29%. The degree of hemolysis in vitro was insignificant and did not exceed 0.01%.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available