Journal
JOURNAL OF ASTHMA AND ALLERGY
Volume 14, Issue -, Pages 1497-1510Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/JAA.S282696
Keywords
food allergy; atopy; desensitization; tolerance; omalizumab; dupilumab; IgE; sustained unresponsiveness
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Oral immunotherapy (OIT) provides an alternative option for pediatric patients with food allergies, showing high efficacy and improving quality of life for patients and their families. Clinical considerations for OIT in pediatrics include efficacy, safety, practical management, and future treatment directions.
Oral immunotherapy (OIT) in pediatric patients provides an alternative option to the current standard of care in food allergy, which is allergen avoidance and reactive treatment. Because patients are exposed to one or more food allergens during treatment, OIT is associated with adverse events and can be a cumbersome process for children, their caregivers, and clinicians. However, there have been an overwhelming number of studies that show high efficacy in both single-and multi-allergen OIT, and that quality of life is greatly improved for both patients and their families after undergoing immunotherapy. This review discusses clinical considerations for OIT in pediatrics, including efficacy and safety, practical management, and future directions of treatment.
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