4.6 Article

Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice

Abigail Boyd et al.

Summary: The study indicates that PDE4 inhibitors induce saliva secretion in mice by activating CFTR, potentially offering therapeutic benefits for conditions like cystic fibrosis and xerostomia. Additionally, the research reveals a potential central/neuronal mechanism of PDE4 inhibitor action in promoting salivation.

BIOCHEMICAL JOURNAL (2021)

Article Pharmacology & Pharmacy

Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice

Ileana Aragon et al.

Summary: The study demonstrates that the inhibition of PDE4 can enhance the anesthetic effects of Isoflurane, with PDE4D playing a key role in this enhancement. Pre-treatment with Naloxone or Propranolol can alleviate the potentiating effect of PDE4 inhibition.

BIOCHEMICAL PHARMACOLOGY (2021)

Review Pharmacology & Pharmacy

The Molecular Biology of Phosphodiesterase 4 Enzymes as Pharmacological Targets: An Interplay of Isoforms, Conformational States, and Inhibitors

Dean Paes et al.

Summary: The PDE4 enzyme family is crucial in regulating cAMP levels and is a therapeutic target for various diseases. PDE4 inhibitors have shown potential, but their clinical use is limited due to a small therapeutic window causing adverse side effects. Targeting specific PDE4 subtypes and isoforms selectively may offer a safer and more effective approach for therapy.

PHARMACOLOGICAL REVIEWS (2021)

Review Pharmacology & Pharmacy

Cyclic nucleotide phosphodiesterases: New targets in the metabolic syndrome?

Claire Lugnier et al.

PHARMACOLOGY & THERAPEUTICS (2020)

Article Chemistry, Medicinal

Advances in the Development of Phosphodiesterase-4 Inhibitors

Ting Peng et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Cell Biology

Phosphodiesterase 4B: Master Regulator of Brain Signaling

Amy J. Tibbo et al.

CELLS (2020)

Article Biochemistry & Molecular Biology

PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice

Will McDonough et al.

FASEB JOURNAL (2020)

Article Immunology

Current insights on clinical efficacy of roflumilast for treatment of COPD, asthma and ACOS

Shradha Bodkhe et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

Review Biotechnology & Applied Microbiology

Therapeutic targeting of 3′,5′-cyclic nucleotide phosphodiesterases: inhibition and beyond

George S. Baillie et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Review Pharmacology & Pharmacy

Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases

Heng Li et al.

FRONTIERS IN PHARMACOLOGY (2018)

Review Cardiac & Cardiovascular Systems

Cyclic nucleotide phosphodiesterases in heart and vessels: A therapeutic perspective

Pierre Bobin et al.

ARCHIVES OF CARDIOVASCULAR DISEASES (2016)

Review Neurosciences

Thermoregulatory disorders and illness related to heat and cold stress

William P. Cheshire

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL (2016)

Article Medicine, General & Internal

Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting

Rudolph M. Navari et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Pharmacology & Pharmacy

Roflumilast for asthma: Safety findings from a pooled analysis of ten clinical studies

P. Chervinsky et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2015)

Article Chemistry, Medicinal

Discovery of triazines as selective PDE4B versus PDE4D inhibitors

Timothy J. Hagen et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)

Review Biotechnology & Applied Microbiology

Advances in targeting cyclic nucleotide phosphodiesterases

Donald H. Maurice et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Article Neurosciences

Mice deficient in phosphodiesterase-4A display anxiogenic-like behavior

Rolf T. Hansen et al.

PSYCHOPHARMACOLOGY (2014)

Article Oncology

Thermoregulatory correlates of nausea in rats and musk shrews

Sukonthar Ngampramuan et al.

ONCOTARGET (2014)

Article Biochemistry & Molecular Biology

Phosphodiesterase 4 and its inhibitors in inflammatory diseases

S.-L.Catherine Jin et al.

Biomedical Journal (2014)

Review Pharmacology & Pharmacy

PDE4 as a target for cognition enhancement

Wito Richter et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2013)

Article Pharmacology & Pharmacy

Evaluation of the Therapeutic Index of a Novel Phosphodiesterase 4B-Selective Inhibitor Over Phosphodiesterase 4D in Mice

Osamu Suzuki et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2013)

Editorial Material Chemistry, Medicinal

PDE Inhibition and cognition enhancement

Arjan Blokland et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2012)

Article Allergy

Phosphodiesterase 4B is essential for TH2-cell function and development of airway hyperresponsiveness in allergic asthma

S. -L. Catherine Jin et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)

Article Biotechnology & Applied Microbiology

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

Alex B. Burgin et al.

NATURE BIOTECHNOLOGY (2010)

Review Biochemistry & Molecular Biology

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

Miles D. Houslay

TRENDS IN BIOCHEMICAL SCIENCES (2010)

Article Biochemistry & Molecular Biology

Identification of PDE4B Over 4D subtype-selective inhibitors revealing an unprecedented binding mode

Michael Kranz et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2009)

Article Chemistry, Medicinal

Discovery of selective PDE4B inhibitors

Kenji Naganuma et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)

Review Neurosciences

Selective phosphodiesterase inhibitors: a promising target for cognition enhancement

Olga A. H. Reneerkens et al.

PSYCHOPHARMACOLOGY (2009)

Article Behavioral Sciences

Why is the neurobiology of nausea and vomiting so important?

Charles C. Horn

APPETITE (2008)

Review Pharmacology & Pharmacy

Subtype Selectivity in Phosphodiesterase 4 (PDE4): A Bottleneck in Rational Drug Design

P. Srivani et al.

CURRENT PHARMACEUTICAL DESIGN (2008)

Article Biochemistry & Molecular Biology

Critical role of PDE4D in β2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts

Matthew D. Bruss et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Multidisciplinary Sciences

EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation

Elaine Huston et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Neurosciences

Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B)

Han-Ting Zhang et al.

NEUROPSYCHOPHARMACOLOGY (2008)

Review Cardiac & Cardiovascular Systems

Overview of PDEs and their regulation

Kenji Omori et al.

CIRCULATION RESEARCH (2007)

Review Pharmacology & Pharmacy

Improving memory: A role for phosphodiesterases

A. Blokland et al.

CURRENT PHARMACEUTICAL DESIGN (2006)

Review Pharmacology & Pharmacy

Phosphodiesterase-4 as a therapeutic target

MD Houslay et al.

DRUG DISCOVERY TODAY (2005)

Article Biochemistry & Molecular Biology

The oligomerization state determines regulatory properties and inhibitor sensitivity of type 4 cAMP-specific phosphodiesterases

W Richter et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Pharmacology & Pharmacy

Antidepressant-induced increase in high-affinity Rolipram binding sites in rat brain: Dependence on noradrenergic and serotonergic function

Y Zhao et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)

Article Multidisciplinary Sciences

Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-α responses

SLC Jin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Pharmacology & Pharmacy

Assessing the emetic potential of PDE4 inhibitors in rats

A Robichaud et al.

BRITISH JOURNAL OF PHARMACOLOGY (2002)

Article Neurosciences

Motion sickness potentiates core cooling during immersion in humans

IB Mekjavic et al.

JOURNAL OF PHYSIOLOGY-LONDON (2001)

Article Neurosciences

PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway

A Robichaud et al.

NEUROPHARMACOLOGY (2001)