Imaging Modalities for Intracranial Aneurysm: More Than Meets the Eye

Intracranial aneurysms (IA) are often asymptomatic and have a prevalence of 3 to 5% in the adult population. The risk of IA rupture is low, however when it occurs half of the patients dies from subarachnoid hemorrhage (SAH). To avoid this fatal evolution, the main treatment is an invasive surgical procedure, which is considered to be at high risk of rupture. This risk score of IA rupture is evaluated mainly according to its size and location. Therefore, angiography and anatomic imaging of the intracranial aneurysm are crucial for its diagnosis. Moreover, it has become obvious in recent years that several other factors are implied in this complication, such as the blood flow complexity or inflammation. These recent findings lead to the development of new IA imaging tools such as vessel wall imaging, 4D-MRI, or molecular MRI to visualize inflammation at the site of IA in human and animal models. In this review, we will summarize IA imaging techniques used for the patients and those currently in development.

Automated summary

Intracranial aneurysms (IA) are often asymptomatic but have a high risk of rupture, leading to death in half of the patients. Invasive surgical procedures are the main treatment, but carry a high risk. Size and location are important indicators for assessing the risk of rupture. Recent findings suggest that factors such as blood flow complexity and inflammation are also involved in this complication, leading to the development of new IA imaging tools.