4.6 Article

Stable Rates of Obstructive Hypertrophic Cardiomyopathy in a Contemporary Era

Related references

Note: Only part of the references are listed.
Article Medicine, General & Internal

Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): health status analysis of a randomised, double-blind, placebo-controlled, phase 3 trial

John A. Spertus et al.

Summary: Mavacamten significantly improved the health status of patients with symptomatic obstructive hypertrophic cardiomyopathy compared to placebo, with a low number needed to treat for marked improvement. Given that the primary goals of treatment are to improve symptoms, physical and social function, and quality of life, mavacamten represents a new potential strategy for achieving these goals.

LANCET (2021)

Article Cardiac & Cardiovascular Systems

Phenotypic Expression and Outcomes in Individuals With Rare Genetic Variants of Hypertrophic Cardiomyopathy

Antonio de Marvao et al.

Summary: Rare variants in sarcomere-encoding genes have low penetrance for overt HCM in middle-aged adults, but are associated with an increased risk of heart failure and a weakened cardiomyopathic phenotype.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

Article Multidisciplinary Sciences

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity

Arjun S. Adhikari et al.

NATURE COMMUNICATIONS (2019)

Article Cardiac & Cardiovascular Systems

Occurrence of Clinically Diagnosed Hypertrophic Cardiomyopathy in the United States

Martin S. Maron et al.

AMERICAN JOURNAL OF CARDIOLOGY (2016)

Review Cardiac & Cardiovascular Systems

Hypertrophic Cardiomyopathy Present and Future, With Translation Into Contemporary Cardiovascular Medicine

Barry J. Maron et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2014)

Article Medicine, General & Internal

Effect of left ventricular outflow tract obstruction on clinical outcome in hypertrophic cardiomyopathy

MS Maron et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)