Journal
COMMUNICATIONS BIOLOGY
Volume 5, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s42003-022-03060-1
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Funding
- China Scholarship Council (CSC)
- Foundation pour la recherche Medicale (FRM) [ANR-10-LABX-0030-INRT]
- French State fund [ANR-10-LABX-0030-INRT, ANR-10-IDEX-0002-02]
- IGBMC
- CNRS
- Fondation ARC pour la recherche sur le cancer
- Institut National du Cancer (INCa)
- Agence Nationale de la Recherche (ANR)
- Ligue Nationale contre le Cancer
- USIAS
- Sanofi iAward Europe
- Programme Federateur Aviesan
- Plan Cancer
- National collaborative project: NANOTUMOR
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This review examines the important roles of non-proteolytic ubiquitylation in cellular signaling and diseases. It provides insights into the functions of non-proteolytic ubiquitylation in cellular processes and its association with the development of human diseases.
Evanthia Pangou and co-authors review recent insights into the important roles of non-proteolytic ubiquitylation in cellular signaling as well as in physiology and disease. Ubiquitylation is one of the most common post-translational modifications (PTMs) of proteins that frequently targets substrates for proteasomal degradation. However it can also result in non-proteolytic events which play important functions in cellular processes such as intracellular signaling, membrane trafficking, DNA repair and cell cycle. Emerging evidence demonstrates that dysfunction of non-proteolytic ubiquitylation is associated with the development of multiple human diseases. In this review, we summarize the current knowledge and the latest concepts on how non-proteolytic ubiquitylation pathways are involved in cellular signaling and in disease-mediating processes. Our review, may advance our understanding of the non-degradative ubiquitylation process.
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