Related references
Note: Only part of the references are listed.Efficient L-Proline catalyzed synthesis of some new (4-substituted-phenyl)-1,5-dihydro-2H-pyrimido[4,5-d][1,3]thiazolo[3,2a]-pyrimidine-2,4(3H)-diones bearing thiazolopyrimidine derivatives and evaluation of their pharmacological activities
S. H. Sukanya et al.
JOURNAL OF MOLECULAR STRUCTURE (2022)
Inhibition of ubiquitin-specific protease 7 sensitizes acute myeloid leukemia to chemotherapy
Maelle Cartel et al.
LEUKEMIA (2021)
A Dual-Acting Nitric Oxide Donor and Phosphodiesterase 5 Inhibitor Promotes Wound Healing in Normal Mice and Mice with Diabetes
Maya Ben-Yehuda Greenwald et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2021)
Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer
Nicole Oatman et al.
SCIENCE ADVANCES (2021)
Synthesis of some novel piperidine fused 5-thioxo-1H-1,2,4-triazoles as potential antimicrobial and antitubercular agents
R. Rishikesan et al.
JOURNAL OF CHEMICAL SCIENCES (2021)
Sepiapterin Reductase Inhibition Leading to Selective Reduction of Inflammatory Joint Pain in Mice and Increased Urinary Sepiapterin Levels in Humans and Mice
Masahide Fujita et al.
ARTHRITIS & RHEUMATOLOGY (2020)
New azole antifungals with a fused triazinone scaffold
David Montoir et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications
Nagaraju Kerru et al.
MOLECULES (2020)
Discovery of Novel Inhibitor for WNT/β-Catenin Pathway by Tankyrase 1/2 Structure-Based Virtual Screening
Bo Li et al.
MOLECULES (2020)
PI3K inhibitors: review and new strategies
Mingzhen Zhang et al.
CHEMICAL SCIENCE (2020)
Discovery, Optimization, and Evaluation of Potent and Highly Selective PI3Kγ-PI3Kδ Dual Inhibitors
Hong Jia et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Stearoyl-CoA Desaturase 1 as a Therapeutic Target for the Treatment of Cancer
Zuzanna Tracz-Gaszewska et al.
CANCERS (2019)
PI3K Inhibitors in Breast Cancer Therapy
Haley Ellis et al.
CURRENT ONCOLOGY REPORTS (2019)
Discovery of a Novel Inhaled PI3Kδ Inhibitor for the Treatment of Respiratory Diseases
Montse Erra et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Discovery of a Potent, Selective, and Orally Available PI3Kδ Inhibitor for the Treatment of Inflammatory Diseases
Montse Erra et al.
ACS MEDICINAL CHEMISTRY LETTERS (2017)
Eg5 inhibitor YL001 induces mitotic arrest and inhibits tumor proliferation
Yufei Wang et al.
ONCOTARGET (2017)
Synthesis of pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones: Rearrangement of pyrrolo[1,2-d][1,3,4]oxadiazines and regioselective intramolecular cyclization of 1,2-biscarbamoyl-substituted 1H-pyrroles
Kkonnip Son et al.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2016)
Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies
Pratik Devasthale et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)
Pyrimidinone Nicotinamide Mimetics as Selective Tankyrase and Wnt Pathway Inhibitors Suitable for in Vivo Pharmacology
Jeffrey W. Johannes et al.
ACS MEDICINAL CHEMISTRY LETTERS (2015)
Discovery of a Phosphodiesterase 9A Inhibitor as a Potential Hypoglycemic Agent
Yong-xian Shao et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among US FDA Approved Pharmaceuticals
Edon Vitaku et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Phosphodiesterase 9: Insights from protein structure and role in therapeutics
Nivedita Singh et al.
LIFE SCIENCES (2014)
Effects on platelet function of an EP3 receptor antagonist used alone and in combination with a P2Y12 antagonist both in-vitro and ex-vivo in human volunteers
S. C. Fox et al.
PLATELETS (2013)
Pyrrolo[1,2-b]pyridazines, pyrrolo[2,1-f]triazin-4(3H)-ones, and related compounds as novel corticotropin-releasing factor 1 (CRF1) receptor antagonists
Tetsuji Saito et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2012)
Chemical space as a source for new drugs
Jean-Louis Reymond et al.
MEDCHEMCOMM (2010)
Antagonists of the EP3 Receptor for Prostaglandin E2 Are Novel Antiplatelet Agents That Do Not Prolong Bleeding
Jasbir Singh et al.
ACS CHEMICAL BIOLOGY (2009)
Vascular wall-produced prostaglandin E2 exacerbates arterial thrombosis and atherothrombosis through platelet EP3 receptors
Sabrina Gross et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors
Kyoung Soon Kim et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Dipeptidyl peptidase IV inhibitors for the treatment of diabetes
AE Weber
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Mechanisms of action of PDE5 inhibition in erectile dysfunction
JD Corbin
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH (2004)
Melanin-concentrating hormone receptor 1 activates extracellular signal-regulated kinase and synergizes with Gs-coupled pathways
P Pissios et al.
ENDOCRINOLOGY (2003)
Overexpression of functionally coupled cyclooxygenase-2 and prostaglandin E synthase in symptomatic atherosclerotic plaques as a basis of prostaglandin E2-dependent plaque instability
F Cipollone et al.
CIRCULATION (2001)