Journal
PHARMACEUTICALS
Volume 14, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/ph14121275
Keywords
pyrrolotriazinone; heterocycle; inhibitor; antagonist
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Heterocyclic amino derivatives have proven to be potent bioactive compounds, with novel heterocycles showing promise as building blocks in drug discovery. Pyrrolotriazinones, in particular, have attracted attention for their potential biological activities.
Heterocyclic amino derivatives have been extensively synthesized and validated as potent bioactive compounds, and nowadays, numerous marketed drugs share these scaffolds, from very simple structures (monoamino, monocyclic compounds) to much more complex molecules (polycyclic derivatives with two or more nitrogen atoms within the (fused) rings). In a constant quest for new chemical entities in drug discovery, a few novel heterocycles have emerged in recent years as promising building blocks for the obtainment of bioactive modulators. In this context, pyrrolotriazinones have attracted attention, and some show promising biological activities. Here, we offer an extensive review of pyrrolo[2,1-f][1,2,4]triazin-4(1H)-one and pyrrolo[1,2-d][1,2,4]triazin-4(3H)-one, describing their biological properties en route to drug discovery.
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