4.6 Article

The Role of LNK (SH2B3) in the Regulation of JAK-STAT Signalling in Haematopoiesis

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK

Rhiannon Morris et al.

Summary: The researchers presented structures of the substrate recognition (SH2) domain of LNK in complex with phosphorylated motifs from JAK2 and EPOR, providing insight into its binding specificity and mode of action.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Highly accurate protein structure prediction with AlphaFold

John Jumper et al.

Summary: Proteins are essential for life, and accurate prediction of their structures is a crucial research problem. Current experimental methods are time-consuming, highlighting the need for accurate computational approaches to address the gap in structural coverage. Despite recent progress, existing methods fall short of atomic accuracy in protein structure prediction.

NATURE (2021)

Article Multidisciplinary Sciences

Monogenic and polygenic inheritance become instruments for clonal selection

Po-Ru Loh et al.

NATURE (2020)

Article Peripheral Vascular Disease

Evidence for a Causal Role of the SH2B3-2M Axis in Blood Pressure Regulation: Framingham Heart Study

Joshua A. Keefe et al.

HYPERTENSION (2019)

Article Multidisciplinary Sciences

LNK suppresses interferon signaling in melanoma

Ling-Wen Ding et al.

NATURE COMMUNICATIONS (2019)

Article Medicine, General & Internal

Essential Thrombocythemia

Ayalew Tefferi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Hematology

LNK mutations and myeloproliferative disorders

Mary Frances McMullin et al.

AMERICAN JOURNAL OF HEMATOLOGY (2016)

Review Urology & Nephrology

Linking inflammation and hypertension via LNK/SH2B3

Bethany L. Dale et al.

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2016)

Article Medicine, Research & Experimental

LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors

Ying Cheng et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Medicine, General & Internal

Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia

K. G. Roberts et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Hematology

Genetic loss of SH2B3 in acute lymphoblastic leukemia

Arianne Perez-Garcia et al.

BLOOD (2013)

Article Medicine, General & Internal

Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms

Thorsten Klampfl et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Review Immunology

The Lnk Adaptor Protein: A Key Regulator of Normal and Pathological Hematopoiesis

Laura Velazquez

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2012)

Article Medicine, Research & Experimental

14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells

Jing Jiang et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Multidisciplinary Sciences

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

Jinghui Zhang et al.

NATURE (2012)

Article Hematology

A nonsynonymous LNK polymorphism associated with idiopathic erythrocytosis

Mary Frances McMullin et al.

AMERICAN JOURNAL OF HEMATOLOGY (2011)

Article Hematology

Adaptor protein Lnk binds to PDGF receptor and inhibits PDGF-dependent signaling

Saskia Gueller et al.

EXPERIMENTAL HEMATOLOGY (2011)

Article Education, Scientific Disciplines

Management of Myelofibrosis

Alessandro M. Vannucchi

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2011)

Article Cell Biology

Adaptor protein Lnk inhibits c-Fms-mediated macrophage function

Saskia Gueller et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2010)

Article Cell Biology

Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F

Sigal Gery et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Adaptor protein Lnk associates with Tyr568 in c-Kit

Saskia Gueller et al.

BIOCHEMICAL JOURNAL (2008)

Article Medicine, Research & Experimental

Link controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2

Alexey Bersenev et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)

Article Biochemistry & Molecular Biology

Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity

Hanyin Cheng et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Article Multidisciplinary Sciences

Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction

Jun Seita et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Biochemistry & Molecular Biology

Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS

Junjie Hu et al.

JOURNAL OF MOLECULAR BIOLOGY (2006)

Article Multidisciplinary Sciences

Suppressor screen in Mpl-/- mice:: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling

MR Carpinelli et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

A phenylalanine zipper mediates APS dimerization

D Dhe-Sirano et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)

Article Immunology

Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis

W Tong et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2004)

Article Biochemistry & Molecular Biology

Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor

JJ Hu et al.

MOLECULAR CELL (2003)

Article Immunology

Cytokine signaling and hematopoietic homeostasis are disrupted in Lnk-deficient mice

L Velazquez et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2002)