Related references
Note: Only part of the references are listed.Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
Hyuna Sung et al.
CA-A CANCER JOURNAL FOR CLINICIANS (2021)
Investigating the structure-activity relationship of marine natural polyketides as promising SARS-CoV-2 main protease inhibitors
Amr El-Demerdash et al.
RSC ADVANCES (2021)
Flavonoids as anticancer therapies: A systematic review of clinical trials
Angela Bisol et al.
PHYTOTHERAPY RESEARCH (2020)
Flavone-based arylamides as potential anticancers: Design, synthesis and in vitro cell-based/cell-free evaluations
Ahmed H. E. Hassan et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Thiazolidine-2,4-dione-based irreversible allosteric IKK-β kinase inhibitors: Optimization into in vivo active anti-inflammatory agents
Ahmed Elkamhawy et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity
Shannon Lee et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Exploring Flavonoids for Potential Inhibitors of a Cancer Signaling Protein PI3Kγ Kinase Using Computational Methods
Mohd Rehan et al.
ANTICANCER RESEARCH (2020)
Flavonoid Nanoparticles: A Promising Approach for Cancer Therapy
Malgorzata Dobrzynska et al.
BIOMOLECULES (2020)
Molecular docking studies, drug-likeness and in-silico ADMET prediction of some novel β-Amino alcohol grafted 1,4,5-trisubstituted 1,2,3-triazoles derivatives as elevators of p53 protein levels
Zakari Ya'u Ibrahim et al.
SCIENTIFIC AFRICAN (2020)
Targeting ERK1/2 protein-serine/threonine kinases in human cancers
Robert Roskoski
PHARMACOLOGICAL RESEARCH (2019)
Molecular determinants as therapeutic targets in cancer chemotherapy: An update
Tanweer Haider et al.
PHARMACOLOGY & THERAPEUTICS (2019)
Virtual Screening of 1,4-Naphthoquinone Derivatives for Inhibition of a Key Cancer Signaling Protein, AKT1 Kinase
Mohd Rehan et al.
ANTICANCER RESEARCH (2019)
Anticancer compound XL765 as PI3K/mTOR dual inhibitor: A structural insight into the inhibitory mechanism using computational approaches
Mohd Rehan
PLOS ONE (2019)
Flavonoids showed anticancer effects on the ovarian cancer cells: Involvement of reactive oxygen species, apoptosis, cell cycle and invasion
Zehra Tavsan et al.
BIOMEDICINE & PHARMACOTHERAPY (2019)
Fisetin Suppresses the Proliferation and Metastasis of Renal Cell Carcinoma through Upregulation of MEK/ERK-Targeting CTSS and ADAM9
Min-Hong Hsieh et al.
CELLS (2019)
Optimization study towards more potent thiazolidine-2,4-dione IKK-β modulator: Synthesis, biological evaluation and in silico docking simulation
Ahmed Elkamhawy et al.
BIOORGANIC CHEMISTRY (2019)
A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer
Cornelia Braicu et al.
CANCERS (2019)
Natural products hybrids: 3,5,4′-Trimethoxystilbene-5,6,7-trimethoxyflavone chimeric analogs as potential cytotoxic agents against diverse human cancer cells
Ahmed H. E. Hassan et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)
Trametinib in the treatment of multiple malignancies harboring MEK1 mutations
Tong Lian et al.
CANCER TREATMENT REVIEWS (2019)
Virtual screening of naphthoquinone analogs for potent inhibitors against the cancer-signaling PI3K/AKT/mTOR pathway
Mohd Rehan et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2019)
Study of Molecular Mechanism of the Interaction Between MEK1/2 and Trametinib with Docking and Molecular Dynamic Simulation
Sh. Hashemzadeh et al.
INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES (2019)
Natural Compounds and Derivatives as Ser/Thr Protein Kinase Modulators and Inhibitors
Barbara Guerra et al.
PHARMACEUTICALS (2019)
被撤回的出版物: Daidzein exerts anticancer activity towards SKOV3 human ovarian cancer cells by inducing apoptosis and cell cycle arrest, and inhibiting the Raf/MEK/ERK cascade (Retracted article. See vol. 47, 2021)
Fu Hua et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2018)
ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway
Andrew M. Kidger et al.
PHARMACOLOGY & THERAPEUTICS (2018)
Anticancer activity of flavonoids isolated from Achyrocline satureioides in gliomas cell lines
Priscila Oliveira de Souza et al.
TOXICOLOGY IN VITRO (2018)
Characterization of flavonoids from fern Cheilanthes tenuifolia and evaluation of antioxidant, antimicrobial and anticancer activities
R. Jarial et al.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE (2018)
An Anti-Cancer Drug Candidate OSI-027 and its Analog as Inhibitors of mTOR: Computational Insights Into the Inhibitory Mechanisms
Mohd Rehan
JOURNAL OF CELLULAR BIOCHEMISTRY (2017)
Antioxidant and anticancer effects and bioavailability studies of the flavonoid baicalin and its oxidovanadium(IV) complex
Juan J. Martinez Medina et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2017)
Current Development Status of MEK Inhibitors
Ying Cheng et al.
MOLECULES (2017)
Apigenin inhibits proliferation and invasion, and induces apoptosis and cell cycle arrest in human melanoma cells
Guangming Zhao et al.
ONCOLOGY REPORTS (2017)
Insights into the binding mode of MEK type-III inhibitors. A step towards discovering and designing allosteric kinase inhibitors across the human kinome
Zheng Zhao et al.
PLOS ONE (2017)
Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen
David Oliver et al.
SCIENTIFIC REPORTS (2017)
Functional evaluation of synthetic flavonoids and chalcones for potential antiviral and anticancer properties
Nelly Mateeva et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)
Allosteric modulators of MEK1: drug design and discovery
Jialin Shang et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2016)
A phenylacetaldehyde-flavonoid adduct, 8-C-(E-phenylethenyl)-norartocarpetin, exhibits intrinsic apoptosis and MAPK pathways-related anticancer potential on HepG2, SMMC-7721 and QGY-7703
Zong-Ping Zheng et al.
FOOD CHEMISTRY (2016)
Structural insights into the polypharmacological activity of quercetin on serine/threonine kinases
Bincy Baby et al.
DRUG DESIGN DEVELOPMENT AND THERAPY (2016)
pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures
Douglas E. V. Pires et al.
JOURNAL OF MEDICINAL CHEMISTRY (2015)
A structural insight into the inhibitory mechanism of an orally active PI3K/mTOR dual inhibitor, PKI-179 using computational approaches
Mohd Rehan
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2015)
Molecular Docking and Structure-Based Drug Design Strategies
Leonardo G. Ferreira et al.
MOLECULES (2015)
MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road
Christopher J. Caunt et al.
NATURE REVIEWS CANCER (2015)
The clinical development of MEK inhibitors
Yujie Zhao et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2014)
Anticancer Compound Plumbagin and Its Molecular Targets: A Structural Insight into the Inhibitory Mechanisms Using Computational Approaches
Mohammad S. Jamal et al.
PLOS ONE (2014)
Computational Insights into the Inhibitory Mechanism of Human AKT1 by an Orally Active Inhibitor, MK-2206
Mohd Rehan et al.
PLOS ONE (2014)
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
Christopher A. Lipinski et al.
ADVANCED DRUG DELIVERY REVIEWS (2012)
MEK1/2 dual-specificity protein kinases: Structure and regulation
Robert Roskoski
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
The Chalcone Flavokawain B Induces G2/M Cell-Cycle Arrest and Apoptosis in Human Oral Carcinoma HSC-3 Cells through the Intracellular ROS Generation and Downregulation of the Akt/p38 MAPK Signaling Pathway
You-Cheng Hseu et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2012)
Prediction of Molecular Targets of Cancer Preventing Flavonoid Compounds Using Computational Methods
Hanyong Chen et al.
PLOS ONE (2012)
LigPlot+: Multiple Ligand-Protein Interaction Diagrams for Drug Discovery
Roman A. Laskowski et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2011)
ProteoConnections: A bioinformatics platform to facilitate proteome and phosphoproteome analyses
Mathieu Courcelles et al.
PROTEOMICS (2011)
Open Babel: An open chemical toolbox
Noel M. O'Boyle et al.
JOURNAL OF CHEMINFORMATICS (2011)
Flavonoids as Protein Kinase Inhibitors for Cancer Chemoprevention: Direct Binding and Molecular Modeling
De-Xing Hou et al.
ANTIOXIDANTS & REDOX SIGNALING (2010)
PyETV: a PyMOL evolutionary trace viewer to analyze functional site predictions in protein complexes
Rhonald C. Lua et al.
BIOINFORMATICS (2010)
In Silico Exploration for Identifying Structure-Activity Relationship of MEK Inhibition and Oral Bioavailability for Isothiazole Derivatives
Georgia Melagraki et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2010)
Software News and Update AutoDock Vina: Improving the Speed and Accuracy of Docking with a New Scoring Function, Efficient Optimization, and Multithreading
Oleg Trott et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2010)
Flavonoids: Recent Advances as Anticancer Drugs
Hai L. Liu et al.
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY (2010)
AutoDock4 and AutoDockTools4: Automated Docking with Selective Receptor Flexibility
Garrett M. Morris et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2009)
A citirus polymethoxyflavonoid, nobiletin, is a novel MEK inhibitoir that exhibits antitumor metastasis in human fibrosarcoma HT-1080 cells
Yoshiki Miyata et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Medicinal plants and cancer chemoprevention
Avni G. Desai et al.
CURRENT DRUG METABOLISM (2008)
Flavonoids as RTK inhibitors and potential anticancer agents
Florence Teillet et al.
MEDICINAL RESEARCH REVIEWS (2008)
Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1
Ki Won Lee et al.
CARCINOGENESIS (2007)
Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance
James A. McCubrey et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
P. J. Roberts et al.
ONCOGENE (2007)
Natural products as sources of new drugs over the last 25 years
David J. Newman et al.
JOURNAL OF NATURAL PRODUCTS (2007)
The flavonoid apigenin inhibits the proliferation of prostatic strornal cells via the MAPK-pathway and cell-cycle arrest in G1/S
Jasmin Bektic et al.
MATURITAS (2006)
Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition
JF Ohren et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2004)
Further development and validation of empirical scoring functions for structure-based binding affinity prediction
RX Wang et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2002)