Journal
PHARMACEUTICALS
Volume 14, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/ph14101015
Keywords
pharmacometabolomics; nuclear magnetic resonance; drug response; personalized medicine; metabolism
Categories
Funding
- European Regional Development Fund (FEDER)
- Spanish Ministry of Economy and Competitiveness [PID2020-115875RB-I00/AEI/10.13039/501100011033]
Ask authors/readers for more resources
Pharmacometabolomics studies focus on predicting individual responses and adverse reactions to drug treatments by analyzing metabolic profiles, which can guide patient selection in clinical trials to enhance drug efficacy and safety. This approach, closely linked to phenotype, provides valuable insights into specific metabolic changes associated with therapeutic interventions.
Pharmacometabolomics (PMx) studies aim to predict individual differences in treatment response and in the development of adverse effects associated with specific drug treatments. Overall, these studies inform us about how individuals will respond to a drug treatment based on their metabolic profiles obtained before, during, or after the therapeutic intervention. In the era of precision medicine, metabolic profiles hold great potential to guide patient selection and stratification in clinical trials, with a focus on improving drug efficacy and safety. Metabolomics is closely related to the phenotype as alterations in metabolism reflect changes in the preceding cascade of genomics, transcriptomics, and proteomics changes, thus providing a significant advance over other omics approaches. Nuclear Magnetic Resonance (NMR) is one of the most widely used analytical platforms in metabolomics studies. In fact, since the introduction of PMx studies in 2006, the number of NMR-based PMx studies has been continuously growing and has provided novel insights into the specific metabolic changes associated with different mechanisms of action and/or toxic effects. This review presents an up-to-date summary of NMR-based PMx studies performed over the last 10 years. Our main objective is to discuss the experimental approaches used for the characterization of the metabolic changes associated with specific therapeutic interventions, the most relevant results obtained so far, and some of the remaining challenges in this area.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available