Journal
JOURNAL OF PERSONALIZED MEDICINE
Volume 12, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/jpm12020289
Keywords
granulomatosis with polyangiitis; vagina; female genital tract; vasculitis; Wegener granulomatosis
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This study conducted a systematic review of the literature on patients with GPA and gynecological involvement. It found that GPA could affect various parts of the genital tract, with the most common site being the uterine cervix. The main symptom was bleeding, but exclusive gynecologic symptomatology was rare. Medical treatment was effective for GPA.
(1) Background: Granulomatosis with polyangiitis (GPA) is a necrotizing vasculitis that mimics gynecologic cancer. In GPA patients, the genitourinary system is affected in <1%. The objective of the study was to provide a systematic review of the literature of GPA patients with gynecological involvement. (2) Methods: PubMed and Embase were searched from inception to July 2021 for GPA patients with gynecological involvement Medical Subject Headings (MeSH) and free-text terms. Exclusion criteria were other language, review articles, pregnancy, fertility, or male patients. Data were extracted on clinical evolution, symptoms, examinations findings, diagnosis delay, treatment, outcome, patient status, and follow-up. (3) Results: Seventeen studies included data from patients with GPA and primary or relapsed gynecological involvement. 68% of the authors of this review thought the patient had cancer. The main gynecological symptom is bleeding, but exclusive gynecologic symptomatology is rare (ENT: 63%, lungs: 44%, kidneys-urinary tract: 53%). GPA could affect all areas of the genital tract, but the most frequent location is the uterine cervix. Medical treatment for GPA is effective. (4) Conclusions: GPA of the female genital tract must be considered when biopsies of an ulcerated malignant-appearing cervical or vaginal mass are negative for malignancy even when they are unspecific. Rheumatology consultation is indicated.
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