Journal
JOURNAL OF PERSONALIZED MEDICINE
Volume 12, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/jpm12020237
Keywords
irradiation; imaging; malperfusion
Ask authors/readers for more resources
This study evaluated tissue perfusion after irradiation of random pattern flaps and found that indocyanine green angiography is more accurate in predicting necrotic areas. Preoperative fractional irradiation with a lower individual dose but a higher total dose has a more negative impact on flap perfusion.
Background: Assessment of tissue perfusion after irradiation of random pattern flaps still remains a challenge. Methods: Twenty-five rats received harvesting of bilateral random pattern fasciocutaneous flaps. Group 1 served as nonirradiated control group. The right flaps of the groups 2-5 were irradiated with 20 Gy postoperatively (group 2), 3 x 12 Gy postoperatively (group 3), 20 Gy preoperatively (group 4) and 3 x 12 Gy preoperatively (group 5). Imaging with infrared thermography, indocyanine green angiography and near-infrared reflectance-based imaging were performed to detect necrotic areas of the flaps. Results: Analysis of the percentage of the necrotic area of the irradiated flaps showed a statistically significant increase from day 1 to 14 only in group 5 (p < 0.05). Indocyanine green angiography showed no differences (p > 0.05) of the percentage of the nonperfused area between all days in group 1 and 3, but a decrease in group 2 in both the left and the right flaps. Infrared thermography and near-infrared reflectance-based imaging did not show evaluable differences. Conclusion: Indocyanine green angiography is more precise in prediction of necrotic areas in random pattern skin flaps when compared to hyperspectral imaging, thermography or clinical impression. Preoperative fractional irradiation with a lower individual dose but a higher total dose has a more negative impact on flap perfusion compared to higher single stage irradiation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available