Journal
ISCIENCE
Volume 24, Issue 10, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.isci.2021.103178
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Funding
- National Institute of Mental Health of the US Na-tional Institutes of Health [R01 MH117996, R01 MH116675]
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The study found that there are progressive changes in prefrontal activity during working memory and response inhibition tasks from adolescence to adulthood, revealing universal properties underlying neuronal computations and the nature of changes that occur as a result of developmental maturation.
Working memory and response inhibition are functions that mature relatively late in life, after adolescence, paralleling the maturation of the prefrontal cortex. The link between behavioral and neural maturation is not obvious, however, making it challenging to understand how neural activity underlies the maturation of cognitive function. To gain insights into the nature of observed changes in prefrontal activity between adolescence and adulthood, we investigated the progressive changes in unit activity of recurrent neural networks as they were trained to perform working memory and response inhibition tasks. These included increased delay period activity during working memory tasks and increased activation in antisaccade tasks. These findings reveal universal properties underlying the neuronal computations behind cognitive tasks and explicate the nature of changes that occur as the result of developmental maturation.
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