4.7 Article

Multi-omics reveals microbiome, host gene expression, and immune landscape in gastric carcinogenesis

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Helicobacter pylori infection has a detrimental impact on the efficacy of cancer immunotherapies

Paul Oster et al.

Summary: This study revealed that Helicobacter pylori infection may reduce the efficacy of cancer immunotherapies, as demonstrated in mouse models and human clinical studies.
Article Gastroenterology & Hepatology

Cancer and the Microbiome-Influence of the Commensal Microbiota on Cancer, Immune Responses, and Immunotherapy

Vyara Matson et al.

Summary: The commensal microbiota plays a role in regulating various physiological processes, including affecting cancer immunotherapy either positively or negatively. Studies have shown that different microbes may have distinct impacts on immunotherapy efficacy, leading to clinical trials and microbiome-based therapeutic interventions.

GASTROENTEROLOGY (2021)

Article Biotechnology & Applied Microbiology

Identification of Genes Universally Differentially Expressed in Gastric Cancer

Yidan Shi et al.

Summary: By identifying individual-level DEGs, this study identified 25 universal DEGs associated with GC, including known cancer genes. These universal DEGs may play a crucial role in GC diagnosis and treatment targets.

BIOMED RESEARCH INTERNATIONAL (2021)

Article Microbiology

Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease

Jonathan Wei Jie Lee et al.

Summary: The intestinal microbiome plays a key role in determining responses to biologic therapy in inflammatory bowel disease. Microbial profiles can help predict clinical therapeutic success and guide the selection of optimal treatments for patients.

CELL HOST & MICROBE (2021)

Article Medicine, General & Internal

STROBE-clinical characteristics and prognosis factors of gastric cancer in young patients aged ≤30 years

Liyun Zhou et al.

Summary: This study found that young patients with GC are often diagnosed at advanced stages with poor prognosis, with tumor size and TNM staging significantly associated with survival. Early screening for GC in young people is crucial to improve outcomes.

MEDICINE (2021)

Article Biochemistry & Molecular Biology

Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

Miles C. Andrews et al.

Summary: The study showed that tumor-associated immune and genomic biomarkers of response to combined immune checkpoint blockade (CICB) in melanoma patients were similar to those of monotherapy, while toxicity from CICB was associated with a more diverse peripheral T-cell repertoire. Additionally, analysis of gut microbiota revealed a higher abundance of Bacteroides intestinalis in patients experiencing toxicity, along with an upregulation of the inflammatory factor IL-1 beta in colitis samples.

NATURE MEDICINE (2021)

Article Gastroenterology & Hepatology

Gastric mucosal microbiota in a Mongolian population with gastric cancer and precursor conditions

Boldbaatar Gantuya et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2020)

Article Cell Biology

H. pylori modulates DC functions via T4SS/TNFα/p38-dependent SOCS3 expression

Muamera Sarajlic et al.

CELL COMMUNICATION AND SIGNALING (2020)

Article Multidisciplinary Sciences

Multiomic blood correlates of genetic risk identify presymptomatic disease alterations

Michael Wainberg et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Biochemistry & Molecular Biology

Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19

Yapeng Su et al.

Article Multidisciplinary Sciences

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

Jason Lloyd-Price et al.

NATURE (2019)

Letter Biotechnology & Applied Microbiology

Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2

Evan Bolyen et al.

NATURE BIOTECHNOLOGY (2019)

Review Oncology

Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy

Tongyan Liu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Review Biotechnology & Applied Microbiology

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

Jerome Galon et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Article Gastroenterology & Hepatology

Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota

Rui M. Ferreira et al.

Article Multidisciplinary Sciences

Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients

V. Gopalakrishnan et al.

SCIENCE (2018)

Article Multidisciplinary Sciences

Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors

Bertrand Routy et al.

SCIENCE (2018)

Article Biotechnology & Applied Microbiology

A wellness study of 108 individuals using personal, dense, dynamic data clouds

Nathan D. Price et al.

NATURE BIOTECHNOLOGY (2017)

Article Biotechnology & Applied Microbiology

xCell: digitally portraying the tissue cellular heterogeneity landscape

Dvir Aran et al.

GENOME BIOLOGY (2017)

Review Oncology

New agents on the horizon in gastric cancer

F. Lordick et al.

ANNALS OF ONCOLOGY (2017)

Review Biotechnology & Applied Microbiology

Multi-omics approaches to disease

Yehudit Hasin et al.

GENOME BIOLOGY (2017)

Review Immunology

SOCS3 and its role in associated diseases

Yanlin Yin et al.

HUMAN IMMUNOLOGY (2015)

Article Biochemical Research Methods

Robust enumeration of cell subsets from tissue expression profiles

Aaron M. Newman et al.

NATURE METHODS (2015)

Article Biochemical Research Methods

Trimmomatic: a flexible trimmer for Illumina sequence data

Anthony M. Bolger et al.

BIOINFORMATICS (2014)

Review Gastroenterology & Hepatology

Immune Response and the Tumor Microenvironment: How They Communicate to Regulate Gastric Cancer

Keunwook Lee et al.

GUT AND LIVER (2014)

Review Pharmacology & Pharmacy

PCNA: a silent housekeeper or a potential therapeutic target?

Shao-Chun Wang

TRENDS IN PHARMACOLOGICAL SCIENCES (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Review Microbiology

Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori

Nina R. Salama et al.

NATURE REVIEWS MICROBIOLOGY (2013)

Article Biochemical Research Methods

SortMeRNA: fast and accurate filtering of ribosomal RNAs in metatranscriptomic data

Evguenia Kopylova et al.

BIOINFORMATICS (2012)

Article Mathematical & Computational Biology

A penalized matrix decomposition, with applications to sparse principal components and canonical correlation analysis

Daniela M. Witten et al.

BIOSTATISTICS (2009)

Article Biochemical Research Methods

GAGE: generally applicable gene set enrichment for pathway analysis

Weijun Luo et al.

BMC BIOINFORMATICS (2009)

Article Gastroenterology & Hepatology

FAT10 level in human gastric cancer and its relation with mutant p53 level, lymph node metastasis and TNM staging

Feng Ji et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2009)

Review Gastroenterology & Hepatology

Epidemiology of gastric cancer

Katherine D. Crew et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2006)