4.7 Article

Transcranial ultrasound stimulation of the human motor cortex

Journal

ISCIENCE
Volume 24, Issue 12, Pages -

Publisher

CELL PRESS
DOI: 10.1016/j.isci.2021.103429

Keywords

-

Funding

  1. National Natural Science Foundation of China [61976136, 61876108, 81822017, 31771215]
  2. Science and Technology Commission of Shanghai Municipality [19441907900, 18JC1420304]
  3. Shanghai Municipal Education Commission -Gaofeng Clinical Medicine Grant Support [20181715]
  4. Medicine and Engineering Interdisciplinary Research Fund of Shanghai Jiao Tong University [ZH2018ZDA30]
  5. Guangdong grant' Key technologies for treatment of brain disorders' [2018B030331001]

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The study found that stimulating the human motor cortex using rTUS may produce long-lasting and statistically significant effects on motor cortex excitability and motor behavior, without observed harmful side effects.
It has been 40 years since the report of long-term synaptic plasticity on the rodent brain. Transcranial ultrasound stimulation (TUS) shows advantages in spatial resolution and penetration depth when compared with electrical or magnetic stimulation. The repetitive TUS (rTUS) can induce cortical excitability alteration on animals, and persit_lent aftereffects were observed. However, the effects of rTUS on synaptic plasticity in humans remain unelucidated. In the current study, we applied a 15-min rTUS protocol to stimulate left primary motor cortex (I-M1) in 24 male healthy participants. The single-pulsed transcranial magnetic stimulation-evoked motor evoked potential and Stop-signal task was applied to measure the rTUS aftereffects. Here, we report that cor. ruing the human motor cortex using rTUS may produce long-lasting and statistical) significant effects on motor cortex excitability as well as motor behavior, without harmful side effects observed. These findings suggest a considerable potential of rTUS in cortical plasticity modulation and clinical intervention for impulsivity-related disorders.

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