Journal
ONE HEALTH
Volume 13, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.onehlt.2021.100322
Keywords
Carbapenemase-producing Enterobacterales; Extended-spectrum beta-lactamase; Transmission; Co-carriage; Companion animal
Funding
- Federal Food Safety and Veterinary Office [FSVO] [1.18.10]
- Swiss National Science Foundation [SNSF] [177378]
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Study in Switzerland found that dogs and cats in veterinary clinics may carry multidrug-resistant organisms for prolonged periods after discharge, while pet-owner co-carriage of the same resistant organisms was not observed.
Background: The emergence and spread of multidrug-resistant organisms (MDROs) represent a threat to human and animal health. Objectives: To assess duration of carriage of MDROs in dogs and cats presented to veterinary clinics/hospitals in Switzerland. To estimate prevalence, duration of and risk factors for MDRO carriage in their owners and the occurrence of co-carriage in owner-pet pairs. Methods: Prospective, longitudinal, observational study. Nasal swabs and fecal samples were collected from 50 owners of dogs and cats presented to 3 large veterinary hospitals, 1 medium-sized clinic and 1 practice. If pet or owner tested positive for a MDRO, follow-up samples were collected for up to 8 months. Methicillin-resistant (MR) Staphylococcus aureus, MR S. pseudintermedius, MR coagulase-negative staphylococci (MRCoNS), MR Macrococcus spp., cephalosporinase-and carbapenemase-producing (CP) Enterobacterales were isolated and further characterized by MALDI-TOF MS, microdilution, beta-lactam resistance gene detection, REP/ERIC-PCR, multilocus sequence typing or whole-genome sequencing. Risk factors for MDRO carriage in owners were explored based on questionnaire-derived data. Results: Five out of 50 owners carried 3rd generation cephalosporin-resistant Enterobacterales (3GC-R-Ent.), and 5/50 MRCoNS. In 3 dogs and 4 cats carriage of 3GC-R-Ent. persisted for up to 136 days after discharge (median 99 days, IQR 83 days, range 36-136 days), in two cats isolates were carbapenem-resistant. Owner-pet co-carriage was not observed. No specific risk factors for MDRO carriage in owners were identified. Conclusions: After discharge from veterinary care, dogs and cats may carry 3GC-R-Ent. for prolonged time periods. Carriage of MDROs was common in owners, but pet-owner co-carriage of the same MDRO was not observed.
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