Journal
BIOMEDICINES
Volume 9, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines9101472
Keywords
urothelial carcinoma; bladder cancer; comparative oncology; basic & translational cancer research; naturally occurring models of cancer; canine cancer; molecular cancer therapeutics
Categories
Funding
- Maxine Adler and Lodric Maddox Fellowship Awards
- UC Davis School of Veterinary Medicine
- VA Merit Award [BX003458]
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This review summarizes the fundamental pathways for canine MIUC initiation, progression, and metastasis, as well as emerging therapeutic targets and mechanisms of drug resistance, proposing new opportunities for potential prognostic and diagnostic biomarkers and therapeutics. Identifying similarities and differences between cancer signaling in dogs and humans is crucial for efficient translation of in vitro research to successful clinical trials for both species.
Muscle-invasive urothelial carcinoma (MIUC) is the most common type of bladder malignancy in humans, but also in dogs that represent a naturally occurring model for this disease. Dogs are immunocompetent animals that share risk factors, pathophysiological features, clinical signs and response to chemotherapeutics with human cancer patients. This review summarizes the fundamental pathways for canine MIUC initiation, progression, and metastasis, emerging therapeutic targets and mechanisms of drug resistance, and proposes new opportunities for potential prognostic and diagnostic biomarkers and therapeutics. Identifying similarities and differences between cancer signaling in dogs and humans is of utmost importance for the efficient translation of in vitro research to successful clinical trials for both species.
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