4.7 Article

Approaching Sites of Action of Temozolomide for Pharmacological and Clinical Studies in Glioblastoma

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

Approaching sites of action of drugs in clinical pharmacology: New analytical options and their challenges

Remi Longuespee et al.

Summary: Clinical pharmacology plays a crucial role in drug development by defining pharmacokinetics and pharmacodynamics. New methods for sample collection and advancements in mass spectrometry now allow for monitoring of drugs at the cellular level, enhancing our understanding of drug efficacy and enabling better simulations for drug development.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2021)

Article Oncology

EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood

Michael Weller et al.

Summary: The European Association of Neuro-Oncology (EANO) has released guidelines for the diagnosis, treatment, and follow-up of adult patients with diffuse gliomas, incorporating major changes in diagnostic algorithms based on the 2016 update of the WHO Classification of Tumors of the Central Nervous System, as well as evidence from recent large clinical trials.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Review Oncology

Recurrent Glioblastoma: From Molecular Landscape to New Treatment Perspectives

Cristina Birzu et al.

Summary: Glioblastoma is the most common and aggressive primary brain cancer in adults. Despite standard treatments including surgery, radiotherapy, and chemotherapy, prognosis remains poor with relapse being common. New treatment options such as immunotherapy and targeted therapy have shown promise in recent years for recurrent cases.

CANCERS (2021)

Article Biochemistry & Molecular Biology

QuPath: The global impact of an open source digital pathology system

M. P. Humphries et al.

Summary: QuPath, created at Queen's University Belfast, is the most widely used image analysis software program globally, addressing various needs in tissue-based image analysis and serving as the system of choice for researchers in scientific research.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2021)

Article Cell Biology

Comparative Analysis of Immunohistochemical Staining Intensity Determined by Light Microscopy, ImageJ and QuPath in Placental Hofbauer Cells

Katerina Cizkova et al.

Summary: The study found that there was almost perfect agreement in staining intensity analysis between ImageJ and QuPath when evaluating Hofbauer cells in placenta samples, while substantial agreement was observed for light microscopy evaluation. Additionally, in 38.1% of samples, all three methods (ImageJ, QuPath, and light microscopy) showed identical immunohistochemical intensity.

ACTA HISTOCHEMICA ET CYTOCHEMICA (2021)

Article Biochemistry & Molecular Biology

Rapid MALDI-MS Assays for Drug Quantification in Biological Matrices: Lessons Learned, New Developments, and Future Perspectives

Margaux Fresnais et al.

Summary: Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has been underutilized in therapeutic drug monitoring due to the complexity of ionization processes. Successful development of MALDI-MS methods requires consideration of matrix-analyte compatibility, matrix crystallization properties, and MS instrumentation. Controlling key parameters, addressing unresolved issues, and considering future perspectives are essential for establishing MALDI-MS as a universal method for drug monitoring.

MOLECULES (2021)

Review Biochemical Research Methods

Microproteomic sample preparation

Michal Alexovic et al.

Summary: Proteomics applications in various fields such as life and health sciences, pathology, and pharmacology often require handling small cell and tissue samples, where microproteomics plays a crucial role in addressing specific considerations for processing these samples efficiently.

PROTEOMICS (2021)

Review Neurosciences

Organoid Models of Glioblastoma and Their Role in Drug Discovery

Matthew J. Rybin et al.

Summary: This review examines a range of organoid-GBM models, discussing their individual strengths and weaknesses, and explores their future applications with a focus on compound screening.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

Article Chemistry, Analytical

Desorption/Ionization-MS Methods for Drug Quantification in Biological Matrices and Their Validation Following Regulatory Guidance

Margaux Fresnais et al.

Summary: Desorption/ionization (DI) methods are crucial for rapid and sensitive drug quantification from solid samples. Validating these methods requires careful consideration of the specific characteristics of DI approaches compared to traditional LC-MS methods.

ANALYTICAL CHEMISTRY (2021)

Review Biochemistry & Molecular Biology

Mitochondrial DNA Methylation and Human Diseases

Andrea Stoccoro et al.

Summary: Epigenetic modifications of the nuclear genome and mitochondrial genome are involved in the pathogenesis of human diseases, with altered methylation levels of mitochondrial DNA found in patients affected by various diseases. Environmental factors and genetic variants can impact mtDNA methylation patterns. Some studies questioned the presence of DNA methylation marks in the mitochondrial genome, while others linked mtDNA methylation to changes in gene transcription and replication, potentially contributing to mitochondrial impairment in human diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Oncology

In Vitro Glioblastoma Models: A Journey into the Third Dimension

Mayra Paolillo et al.

Summary: This review highlights the challenges and advancements in glioblastoma modeling, focusing on 3D in vitro models. It discusses the features and classification of glioblastoma, as well as the advantages and disadvantages of different 3D models available in the literature. Efforts have been made to develop reliable and affordable in vitro models to address the limitations of classical 2D cell culture systems and to screen potential drugs for glioblastoma.

CANCERS (2021)

Article Spectroscopy

UV spectroscopic method for estimation of temozolomide: Application in stability studies in simulated plasma pH, degradation rate kinetics, formulation design, and selection of dissolution media

Tejashree Waghule et al.

Summary: This research developed analytical methods for estimating temozolomide (TMZ) content, validated their reliability in stability samples and nanoformulations. The study explored TMZ stability and degradation kinetics under various pH conditions, finding first-order kinetics conversions. The developed methods accurately estimated TMZ concentration and were suitable for lipid nanoformulations.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2021)

Review Biochemical Research Methods

Decoding Post-Translational Modification Crosstalk With Proteomics

Mario Leutert et al.

Summary: Post-translational modifications (PTMs) play a crucial role in regulating protein functions and diversifying the proteome. PTM crosstalk, the interaction between multiple PTMs on the same or different proteins, has been elucidated through advanced proteomic technologies, mass spectrometry instrumentation, and bioinformatics, providing insights into the functional consequences of these interactions.

MOLECULAR & CELLULAR PROTEOMICS (2021)

Article Biochemical Research Methods

Nucleobase derivatives induce in-source decay of oligonucleotides as new matrix-assisted laser desorption/ionization matrices

Satoshi Kimura et al.

RAPID COMMUNICATIONS IN MASS SPECTROMETRY (2020)

Article Biochemical Research Methods

8-Hydroxyguanosine as a possible RNA oxidative modification marker in urine from colorectal cancer patients: Evaluation by ultra performance liquid chromatography-tandem mass spectrometry

Cheng Guo et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2020)

Article Biochemical Research Methods

Rapid and Sensitive Drug Quantification in Tissue Sections Using Matrix Assisted Laser Desorption Ionization-Ion Mobility-Mass Spectrometry Profiling

Margaux Fresnais et al.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2020)

Article Biochemistry & Molecular Biology

Automated sample preparation with SP3 for low-input clinical proteomics

Torsten Mueller et al.

MOLECULAR SYSTEMS BIOLOGY (2020)

Review Oncology

IDH mutation in glioma: molecular mechanisms and potential therapeutic targets

Sue Han et al.

BRITISH JOURNAL OF CANCER (2020)

Review Biochemistry & Molecular Biology

Deoxyribonucleases and Their Applications in Biomedicine

Lucia Laukova et al.

BIOMOLECULES (2020)

Review Biochemical Research Methods

Microdissection-An Essential Prerequisite for Spatial Cancer Omics

Ferdinand von Eggeling et al.

PROTEOMICS (2020)

Article Biochemical Research Methods

Cytomine: Toward an Open and Collaborative Software Platform for Digital Pathology Bridged to Molecular Investigations

Ulysse Rubens et al.

PROTEOMICS CLINICAL APPLICATIONS (2019)

Article Biochemical Research Methods

Site-to-Site Reproducibility and Spatial Resolution in MALDI-MSI of Peptides from Formalin-Fixed Paraffin-Embedded Samples

Alice Ly et al.

PROTEOMICS CLINICAL APPLICATIONS (2019)

Review Biochemistry & Molecular Biology

Temozolomide and Other Alkylating Agents in Glioblastoma Therapy

Hannah Strobel et al.

BIOMEDICINES (2019)

Review Pharmacology & Pharmacy

Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response

Sabine Hombach-Klonisch et al.

PHARMACOLOGY & THERAPEUTICS (2018)

Article Biochemical Research Methods

Blood-brain-barrier organoids for investigating the permeability of CNS therapeutics

Sonja Bergmann et al.

NATURE PROTOCOLS (2018)

Review Cell Biology

Post-transcriptional gene regulation by mRNA modifications

Boxuan Simen Zhao et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Article Multidisciplinary Sciences

Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

Choi-Fong Cho et al.

NATURE COMMUNICATIONS (2017)

Review Oncology

Chemotherapeutic Drugs: DNA Damage and Repair in Glioblastoma

Laura Annovazzi et al.

CANCERS (2017)

Article Multidisciplinary Sciences

QuPath: Open source software for digital pathology image analysis

Peter Bankhead et al.

SCIENTIFIC REPORTS (2017)

Article Biochemical Research Methods

A fully validated bioanalytical method using an UHPLC-MS/MS system for quantification of DNA and RNA oxidative stress biomarkers

Barbora Cervinkova et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2017)

Article Biochemical Research Methods

Collaborative analysis of multi-gigapixel imaging data using Cytomine

Raphael Maree et al.

BIOINFORMATICS (2016)

Article Biochemical Research Methods

Development, validation and application of a fast analytical methodology for the simultaneous determination of DNA- and RNA-derived urinary nucleosides by liquid chromatography coupled to tandem mass spectrometry

Encarnacion Rodriguez-Gonzalo et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2016)

Review Biochemical Research Methods

MALDI mass spectrometry imaging: A cutting-edge tool for fundamental and clinical histopathology

Remi Longuespee et al.

PROTEOMICS CLINICAL APPLICATIONS (2016)

Review Chemistry, Multidisciplinary

Mass spectrometry for the assessment of the occurrence and biological consequences of DNA adducts

Shuo Liu et al.

CHEMICAL SOCIETY REVIEWS (2015)

Review Cell Biology

Non-histone protein methylation as a regulator of cellular signalling and function

Kyle K. Biggar et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)

Article Multidisciplinary Sciences

Non-Enzymatic Depurination of Nucleic Acids: Factors and Mechanisms

Ran An et al.

PLOS ONE (2014)

Article Biochemistry & Molecular Biology

Depurination of N7-Methylguanine by DNA Glycosylase AlkD Is Dependent on the DNA Backbone

Emily H. Rubinson et al.

BIOCHEMISTRY (2013)

Article Biochemical Research Methods

Simultaneous quantification of methylated purines in DNA by isotope dilution LC-MS/MS coupled with automated solid-phase extraction

Chiung-Wen Hu et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2012)

Review Biochemistry & Molecular Biology

DNA glycosylases: in DNA repair and beyond

Angelika L. Jacobs et al.

CHROMOSOMA (2012)

Article Chemistry, Medicinal

admetSAR: A Comprehensive Source and Free Tool for Assessment of Chemical ADMET Properties

Feixiong Cheng et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)

Article Oncology

Proteomics Pipeline for Biomarker Discovery of Laser Capture Microdissected Breast Cancer Tissue

Ning Qing Liu et al.

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2012)

Article Biochemistry & Molecular Biology

Temozolomide: Mechanisms of Action, Repair and Resistance

Jihong Zhang et al.

Current Molecular Pharmacology (2011)

Review Biochemical Research Methods

Stable-isotope dilution LC-MS for quantitative biomarker analysis

Eugene Ciccimaro et al.

BIOANALYSIS (2010)

Article Cell Biology

Enzymes used in molecular biology: a useful guide

Laure Rittie et al.

JOURNAL OF CELL COMMUNICATION AND SIGNALING (2008)

Article Biochemical Research Methods

Simultaneous quantitation of 7-methyl- and O6-methylguanine adducts in DNA by liquid chromatography-positive electrospray tandem mass spectrometry

FG Zhang et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2006)

Article Chemistry, Multidisciplinary

Activation barriers for DNA alkylation by carcinogenic methane diazonium ions

KS Ekanayake et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2006)

Article Biochemical Research Methods

MALDI-TOF MS analysis of urinary nucleosides

B Kammerer et al.

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY (2005)

Article Biochemical Research Methods

A comparison of enzymatic digestion for the quantitation of an oligonucleotide by liquid chromatography-isotope dilution mass spectrometry

CE Donald et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2005)

Article Medicine, General & Internal

MGMT gene silencing and benefit from temozolomide in glioblastoma

ME Hegi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Medicine, General & Internal

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

R Stupp et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Biochemistry & Molecular Biology

Identification of bifunctional GA and AG intrastrand crosslinks formed between cisplatin and DNA

R Gupta et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2005)

Review Oncology

Cost of migration: Invasion of malignant gliomas and implications for treatment

A Giese et al.

JOURNAL OF CLINICAL ONCOLOGY (2003)

Article Chemistry, Analytical

Direct isolation of purines and pyrimidines from nucleic acids using sublimation

DP Glavin et al.

ANALYTICAL CHEMISTRY (2002)

Article Multidisciplinary Sciences

A DNA enzyme with N-glycosylase activity

TL Sheppard et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)