Journal
BIOMEDICINES
Volume 9, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines9111564
Keywords
DNA repair; cancer; ultraviolet; ROS; DNA-photolyase; cryptochrome; molecular evolution
Categories
Funding
- Ministry of Science and Higher Education of the Russian Federation [FMFG-2019-0024]
Ask authors/readers for more resources
Prolonged exposure to ultraviolet radiation can cause serious damage to human skin, including the risk of skin cancer. Most mammals have lost the ability for DNA photorepair, but retained closely related cryptochromes that regulate the nucleotide excision repair system.
Prolonged exposure to ultraviolet radiation on human skin can lead to mutations in DNA, photoaging, suppression of the immune system, and other damage up to skin cancer (melanoma, basal cell, and squamous cell carcinoma). We reviewed the state of knowledge of the damaging action of UVB and UVA on DNA, and also the mechanisms of DNA repair with the participation of the DNA-photolyase enzyme or of the nucleotide excision repair (NER) system. In the course of evolution, most mammals lost the possibility of DNA photoreparation due to the disappearance of DNA photolyase genes, but they retained closely related cryptochromes that regulate the transcription of the NER system enzymes. We analyze the published relationships between DNA photolyases/cryptochromes and carcinogenesis, as well as their possible role in the prevention and treatment of diseases caused by UV radiation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available