Protective Role of Combined Polyphenols and Micronutrients against Influenza A Virus and SARS-CoV-2 Infection In Vitro

Article Integrative & Complementary Medicine

Inhibitory effect of honokiol on furin-like activity and SARS-CoV-2 infection

Takashi Tanikawa et al.

Summary: This study found that honokiol has a remarkable inhibitory effect on SARS-CoV-2 infection, suggesting that honokiol and related traditional Chinese medicine may be potential therapeutic agents for treating SARS-CoV-2.

JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE (2022)

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Review Medical Laboratory Technology

The COVID-19 pandemic: viral variants and vaccine efficacy

Marco Ciotti et al.

Summary: The article discusses the development of COVID-19 vaccines, the impact of viral variants on transmission and virus antibodies, and methods for measuring vaccine antibody responses. It also emphasizes the importance of using the WHO International Standard to accurately calibrate immunoassays.

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES (2022)

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Review Pharmacology & Pharmacy

Targeting cellular senescence in cancer by plant secondary metabolites: A systematic review

Sajad Fakhri et al.

Summary: Senescence plays a dual role in tumor growth suppression and development of tumorigenic state in nearby cells. Natural secondary metabolites have shown promise in targeting senescence-associated mediators and pathways, making them potential anticancer agents.

PHARMACOLOGICAL RESEARCH (2022)

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Letter Nutrition & Dietetics

Polydatin and COVID-19

Viroj Wiwanitkit

CLINICAL NUTRITION (2022)

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Article Nutrition & Dietetics

Glucose-6-phosphate dehydrogenase inhibitor for treatment of severe COVID-19: Polydatin

Amir Hossein Doustimotlagh et al.

Summary: The COVID-19 pandemic is considered an emergency, with the best current treatment option possibly being the search for an FDA-approved drug. Inhibiting G6PD activity to improve disease progression may be an effective strategy.

CLINICAL NUTRITION ESPEN (2021)

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Article Plant Sciences

Shufeng Jiedu, a promising herbal therapy for moderate COVID-19: Antiviral and anti-inflammatory properties, pathways of bioactive compounds, and a clinical real-world pragmatic study

Lu Xia et al.

Summary: The study demonstrated that Shufeng Jiedu capsules have antiviral and anti-inflammatory properties, significantly reducing virus load and inflammatory factors in COVID-19 patients while increasing immune cell levels. Clinical data showed that SFJDC therapy was most effective when initiated within the first 8 days after symptom onset.

PHYTOMEDICINE (2021)

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Review Immunology

COVID-19: A review of therapeutic strategies and vaccine candidates

Vladislav Izda et al.

Summary: The COVID-19 pandemic has become a major global public health crisis, prompting urgent efforts in the scientific community to search for therapeutic and preventative solutions, including the development of pharmacological therapies and vaccines. This article aims to review the latest data on pharmacological therapies undergoing clinical trials and vaccine candidates in development to combat COVID-19.

CLINICAL IMMUNOLOGY (2021)

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Editorial Material Critical Care Medicine

Influence of IL-6 levels on patient survival in COVID-19

Nishkantha Arulkumaran et al.

JOURNAL OF CRITICAL CARE (2021)

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Article Infectious Diseases

SARS-CoV-2 infection: the environmental endurance of the virus can be influenced by the increase of temperature

Fabio Magurano et al.

Summary: The study found that the survival time of coronavirus on plastic surfaces is influenced by temperature, with high temperatures reducing the virus's ability to survive. The research showed differences in virus survival at room temperature and June temperature, which may help us better understand the transmission patterns of the novel coronavirus.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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Article Biochemistry & Molecular Biology

Temporin G, an amphibian antimicrobial peptide against influenza and parainfluenza respiratory viruses: Insights into biological activity and mechanism of action

M. De Angelis et al.

Summary: The antimicrobial peptide temporin G (TG) showed significant inhibition of early phases of influenza virus replication by interacting with the viral hemagglutinin (HA) protein. Additionally, TG demonstrated an inhibitory effect on parainfluenza virus replication, possibly by blocking some late steps of viral replication. These findings suggest a new therapeutic avenue for combating respiratory viruses with different cell entry mechanisms, including SARS-CoV2.

FASEB JOURNAL (2021)

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Review Environmental Sciences

Polyphenols and their potential role to fight viral diseases: An overview

Maria Fernanda Montenegro-Landivar et al.

Summary: Fruits, vegetables, spices, and herbs contain phenolic acids and polyphenols, which provide important benefits to human health such as antioxidant, anti-inflammatory, anticancer, and antiviral properties. Polyphenols have shown great potential against various viruses and their diverse action mechanisms make them a promising strategy for treating or preventing viral infections. Antiviral polyphenols can also be utilized to develop natural antiviral drugs with minimal side effects.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

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Review Nutrition & Dietetics

Plant-Derived Food Grade Substances (PDFGS) Active Against Respiratory Viruses: A Systematic Review of Non-clinical Studies

Francis U. Umeoguaju et al.

Summary: This study investigated the potential of plant-derived food grade substances (PDFGS) in inhibiting human pathogenic viruses infecting the respiratory tract. The results showed that PDFGS can interfere with various stages of viral replication, reduce viral-induced damages, and improve cellular homeostasis, leading to decreased virus titer and improved survival of host cells. Major active food constituents against respiratory viruses include flavonoids, phenolic acids, tannins, lectins, vitamin D, curcumin, and plant glycosides.

FRONTIERS IN NUTRITION (2021)

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Review Biochemistry & Molecular Biology

Dietary and Protective Factors to Halt or Mitigate Progression of Autoimmunity, COVID-19 and Its Associated Metabolic Diseases

Camillo Ricordi et al.

Summary: COVID-19 is the worst pandemic since H1N1, and while vaccination is increasing, a feasible approach for prevention and therapy is still needed. Metabolic diseases may be linked to severe COVID-19, and dietary factors could play a key role in preventing disease progression. Various agents could inhibit severe COVID-19 characteristics, and rigorous studies are essential for validating preventive and therapeutic protocols.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Gastroenterology & Hepatology

Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy

Matthew J. McConnell et al.

Summary: Analysis of COVID-19 patients suggests that IL-6 trans-signaling may cause hepatic endotheliopathy and blood clot formation, leading to liver injury.

JOURNAL OF HEPATOLOGY (2021)

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Article Chemistry, Multidisciplinary

Pomegranate Peel Extract as an Inhibitor of SARS-CoV-2 Spike Binding to Human ACE2 Receptor (in vitro): A Promising Source of Novel Antiviral Drugs

Annalisa Tito et al.

Summary: Plant extracts rich in bioactive compounds may have antiviral activities against SARS-CoV-2, presenting new opportunities for innovative therapies in the fight against the virus.

FRONTIERS IN CHEMISTRY (2021)

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Article Infectious Diseases

The correlation between serum selenium, zinc, and COVID-19 severity: an observational study

Soodeh Razeghi Jahromi et al.

Summary: The study aimed to evaluate the correlation between serum selenium and zinc levels and COVID-19 severity. The results showed that increasing levels of selenium and zinc were associated with a decrease in serum CRP levels in COVID-19 patients. However, the significant association between selenium, zinc, and disease severity was lost after adjusting for confounding factors.

BMC INFECTIOUS DISEASES (2021)

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Review Biochemistry & Molecular Biology

The Involvement of Natural Polyphenols in the Chemoprevention of Cervical Cancer

Georgiana Dretcanu et al.

Summary: Cervical cancer ranks among the top four most frequent types of cancer, with treatment options including surgical interventions and chemoradiotherapy. However, these methods come with significant adverse effects, leading to a growing focus on alternative medicine, specifically phytochemicals, for more effective treatments. Studies are aiming to find new chemopreventive agents with less toxicity but high effectiveness, with polyphenols showing promising potential in cervical cancer prevention.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Identification of SARS-CoV-2 Receptor Binding Inhibitors by In Vitro Screening of Drug Libraries

Alon Ben David et al.

Summary: This study developed an in vitro RBD-ACE2 binding assay and identified three compounds that effectively inhibit the interaction of SARS-CoV-2 with ACE2. These compounds show potential for COVID-19 therapy and molecular docking analysis revealed their binding sites in the RBD, offering insights for further drug discovery efforts against SARS-CoV-2.

MOLECULES (2021)

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Review Virology

SARS-CoV-2 Infection: New Molecular, Phylogenetic, and Pathogenetic Insights. Efficacy of Current Vaccines and the Potential Risk of Variants

John Charles Rotondo et al.

Summary: SARS-CoV-2 has caused the COVID-19 pandemic, leading to significant global health concerns. Despite scientific advancements, understanding of the virus remains limited. The development and deployment of vaccines has shown positive effects, but the emergence of new variants poses challenges to controlling and eradicating the infection.

VIRUSES-BASEL (2021)

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Article Virology

Resveratrol and Pterostilbene Inhibit SARS-CoV-2 Replication in Air-Liquid Interface Cultured Human Primary Bronchial Epithelial Cells

Bram M. ter Ellen et al.

Summary: Resveratrol and its metabolically stable analog, pterostilbene, exhibit potent antiviral properties against SARS-CoV-2 in vitro, actively inhibiting virus replication and showing long-lasting effects. They also demonstrate strong antiviral activity in respiratory cells infected with the virus, highlighting their potential as promising antiviral compounds for inhibiting SARS-CoV-2 infection. Further evaluation in clinical trials is recommended before confirming their efficacy for COVID-19 treatment.

VIRUSES-BASEL (2021)

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Article Cell Biology

Low level of plasminogen increases risk for mortality in COVID-19 patients

David Della-Morte et al.

Summary: This study found a significant association between low plasminogen levels and inflammatory markers, coagulation markers, and organ dysfunction markers in COVID-19 patients. Plasminogen may play a vital role in controlling the complex mechanisms behind the complications of COVID-19, serving as both a biomarker for prognosis and a potential therapeutic target.

CELL DEATH & DISEASE (2021)

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Review Nutrition & Dietetics

Polyphenols and Ischemic Stroke: Insight into One of the Best Strategies for Prevention and Treatment

Francesca Pacifici et al.

Summary: This article reviewed the association between polyphenols and stroke protection, including prevention, acute phase effects, and rehabilitation. These compounds have clinical relevance in reducing vascular risk factors for stroke.

NUTRIENTS (2021)

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Article Biochemistry & Molecular Biology

Interference of Polydatin/Resveratrol in the ACE2:Spike Recognition during COVID-19 Infection. A Focus on Their Potential Mechanism of Action through Computational and Biochemical Assays

Fulvio Perrella et al.

Summary: In the search for new therapeutic strategies against SARS-CoV-2, the study found that the natural polyphenols polydatin and resveratrol can interact with the viral protein Spike and the host receptor ACE2, with polydatin showing stronger inhibitory activity against ACE2:Spike recognition compared to resveratrol.

BIOMOLECULES (2021)

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Review Integrative & Complementary Medicine

Natural Supplements for COVID19-Background, Rationale, and Clinical Trials

Melody Hermel et al.

Summary: The authors reviewed the evidence and rationale for the use of natural supplements for prevention and treatment of COVID-19, considering both potential benefits and harms. They critically evaluated biomedical literature from peer-reviewed journals, preprint servers, and guidelines recommended by expert bodies, as well as ongoing and future registered trials. The review aims to provide clinicians with necessary information to facilitate discussions with patients about the evidence for and potential risks of using dietary supplements for COVID-19 prevention and treatment.

JOURNAL OF EVIDENCE-BASED INTEGRATIVE MEDICINE (2021)

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Article Infectious Diseases