☆ 4.7 Article

Cytoprotective Effect of Idebenone through Modulation of the Intrinsic Mitochondrial Pathway of Apoptosis in Human Retinal Pigment Epithelial Cells Exposed to Oxidative Stress Induced by Hydrogen Peroxide

BIOMEDICINES (2022)

Related references

Note: Only part of the references are listed.

Article Biology

Idebenone Decreases Aβ Pathology by Modulating RAGE/Caspase-3 Signaling and the Aβ Degradation Enzyme NEP in a Mouse Model of AD

Hyun-ju Lee et al.

Summary: The study found that idebenone can modulate the pathology of Alzheimer's disease in 5xFAD mice through various pathways, including reducing Aβ plaque numbers, increasing Aβ degradation enzyme and alpha-secretase levels, and suppressing tau kinase levels, suggesting its therapeutic potential for AD.

BIOLOGY-BASEL (2021)

Add to Collection

Article Medicine, Research & Experimental

Plasma idebenone monitoring in Friedreich's ataxia patients during a long-term follow-up

Abraham J. Paredes-Fuentes et al.

Summary: This study aimed to report plasma idebenone values in a cohort of Friedreich's ataxia (FRDA) patients during long-term follow-up. The results showed marked variations in idebenone levels among patients, with no consistent positive effect observed after analysis of paired data. Additionally, a correlation was found between some cardiological measures and the duration of idebenone therapy at high doses.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Add to Collection

Article Ophthalmology

Leber's hereditary optic neuropathy: course of disease in consideration of idebenone treatment and type of mutation

Felix Tonagel et al.

Summary: The study investigated two cohorts of LHON patients, with one receiving no medication and the other receiving a daily dose of 900 mg idebenone. The findings suggest that idebenone may improve vision in some LHON patients, with three out of seven patients in the treated cohort experiencing visual acuity recovery.

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Novel Short-Chain Quinones to Treat Vision Loss in a Rat Model of Diabetic Retinopathy

Abraham Daniel et al.

Summary: Diabetic retinopathy is a common cause of blindness, with mitochondrial dysfunction and oxidative stress playing a central role in the disease. Mitoprotective compounds, particularly short-chain quinones, show potential for effective and fast-acting treatment against DR in a rat model.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Idebenone: When an antioxidant is not an antioxidant

Nuri Gueven et al.

Summary: Idebenone is widely described as an antioxidant drug, but there is a significant discrepancy between its pharmacokinetics and achievable tissue levels in target tissues, casting doubt on our current understanding. A new framework has been proposed based on recent discoveries to explain its mode of action, providing a rational approach for testing its effects in novel indications.

REDOX BIOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Cytoprotective Effects of Punicalagin on Hydrogen-Peroxide-Mediated Oxidative Stress and Mitochondrial Dysfunction in Retinal Pigment Epithelium Cells

Maria Elisabetta Clementi et al.

Summary: The study indicates that punicalagin (PUN) from pomegranate can effectively protect against mitochondrial dysfunction, reduce oxidative stress, and decrease cellular apoptosis in retinal pigment epithelium (RPE) cells. This suggests that PUN may serve as a beneficial nutraceutical agent in treating oxidation-associated disorders of RPE.

ANTIOXIDANTS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Effectiveness of idebenone nanorod formulations in the treatment of Alzheimer's disease

Yuying Huang et al.

Summary: The study successfully fabricated IDB nanorods to enhance oral bioavailability and increase concentrations in the brain, improving the therapeutic effects of IDB in the treatment of Alzheimer's disease.

JOURNAL OF CONTROLLED RELEASE (2021)

Add to Collection

Review Pharmacology & Pharmacy

Functions and Diseases of the Retinal Pigment Epithelium

Song Yang et al.

Summary: The retinal pigment epithelium is crucial for visual functions, but damage to its structure and function can lead to various retinopathies with no cure currently available. Understanding the development, function, and pathobiology of the retinal pigment epithelium is essential for preventing and treating retinopathies. This review discusses potential strategies for treatment and provides new perspectives for future research in this field.

FRONTIERS IN PHARMACOLOGY (2021)

Add to Collection

Review Chemistry, Multidisciplinary

The Relationship between Mitochondria and Neurodegeration in the Eye: A Review

Hongtao Liu et al.

Summary: Mitochondria are crucial energy producers in cells, and their dysfunction can impact cell function, potentially leading to neurodegenerative diseases in the eye. Research on mechanisms of mitochondrial damage, repair post-injury, and their roles in various eye tissues have implications for treating glaucoma by reducing damage and promoting repair.

APPLIED SCIENCES-BASEL (2021)

Add to Collection

Article Clinical Neurology

Therapeutic Effect of Idebenone on Rats with Vascular Dementia via the MicroRNA-216a/RSK2/NF-κB Axis

Xudong Qian et al.

Summary: This study showed that Idebenone can inhibit the activation of RSK2/IκBα/NF-κB axis in VD rats by increasing miR-216a expression, thereby alleviating oxidative stress and neuroinflammation.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2021)

Add to Collection

Review Cell Biology

Nrf2-ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms

Pallab Shaw et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2020)

Add to Collection

Article Clinical Neurology

Long-term data with idebenone on respiratory function outcomes in patients with Duchenne muscular dystrophy

Laurent Servais et al.

NEUROMUSCULAR DISORDERS (2020)

Add to Collection

Article Neurosciences

Idebenone Has Distinct Effects on Mitochondrial Respiration in Cortical Astrocytes Compared to Cortical Neurons Due to Differential NQO1 Activity

Sausan M. Jaber et al.

JOURNAL OF NEUROSCIENCE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Punicalagin Protects Human Retinal Pigment Epithelium Cells from Ultraviolet Radiation-Induced Oxidative Damage by Activating Nrf2/HO-1 Signaling Pathway and Reducing Apoptosis

Maria Elisabetta Clementi et al.

ANTIOXIDANTS (2020)

Add to Collection

Article Clinical Neurology

Real-World Clinical Experience With Idebenone in the Treatment of Leber Hereditary Optic Neuropathy

Claudia B. Catarino et al.

JOURNAL OF NEURO-OPHTHALMOLOGY (2020)

Add to Collection

Review Cell Biology

Not All Stressors Are Equal: Mechanism of Stressors on RPE Cell Degeneration

Yao Tong et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Add to Collection

Article Medicine, Research & Experimental

DHA protects PC12 cells against oxidative stress and apoptotic signals through the activation of the NFE2L2/HO-1 axis

Maria Elisabetta Clementi et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Targeting NRF2 for the Treatment of Friedreich's Ataxia: A Comparison among Drugs

Sara Petrillo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Add to Collection

Article Neurosciences

Punicalagin reduces H2O2-induced cytotoxicity and apoptosis in PC12 cells by modulating the levels of reactive oxygen species

Maria Elisabetta Clementi et al.

NUTRITIONAL NEUROSCIENCE (2018)

Add to Collection

Review Physiology

THE KEAP1-NRF2 SYSTEM: A THIOL-BASED SENSOR-EFFECTOR APPARATUS FOR MAINTAINING REDOX HOMEOSTASIS

Masayuki Yamamoto et al.

PHYSIOLOGICAL REVIEWS (2018)

Add to Collection

Review Pharmacology & Pharmacy

Oxidative Stress in Age-Related Macular Degeneration: Nrf2 as Therapeutic Target

Ilaria Bellezza

FRONTIERS IN PHARMACOLOGY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

MOMP, cell suicide as a BCL-2 family business

Halime Kalkavan et al.

CELL DEATH AND DIFFERENTIATION (2018)

Add to Collection

Article Cell Biology

Targeting mitochondrial function to treat optic neuropathy

Nuri Gueven et al.

MITOCHONDRION (2017)

Add to Collection

Letter Clinical Neurology

Idebenone in Friedreich ataxia and Leber's hereditary optic neuropathy: close mechanisms, similar therapy?

Manuel Schiff et al.

BRAIN (2016)

Add to Collection

Review Pharmacology & Pharmacy

Idebenone: A Review in Leber's Hereditary Optic Neuropathy

Katherine A. Lyseng-Williamson

DRUGS (2016)

Add to Collection

Article Pharmacology & Pharmacy

Pharmacology of the retinal pigment epithelium, the interface between retina and body system

Olaf Strauss

EUROPEAN JOURNAL OF PHARMACOLOGY (2016)

Add to Collection

Article Medicine, General & Internal

Efficacy of idebenone on respiratory function in patients with Duchenne muscular dystrophy not using glucocorticoids (DELOS): a double-blind randomised placebo-controlled phase 3 trial

Gunnar M. Buyse et al.

LANCET (2015)

Add to Collection

Article Ophthalmology

Idebenone Prevents Oxidative Stress, Cell Death and Senescence of Retinal Pigment Epithelium Cells by Stabilizing BAX/Bcl-2 Ratio

Nicole Arend et al.

OPHTHALMOLOGICA (2015)

Add to Collection

Review Biochemistry & Molecular Biology

Border between natural product and drug: Comparison of the related benzoquinones idebenone and coenzyme Q(10)

Nuni Gueyen et al.

REDOX BIOLOGY (2015)

Add to Collection

Review Biochemistry & Molecular Biology

Co-enzyme Q10 and idebenone use in Friedreich's ataxia

Michael H. Parkinson et al.

JOURNAL OF NEUROCHEMISTRY (2013)

Add to Collection

Article Biochemistry & Molecular Biology

Nrf2 Protein Up-regulates Antiapoptotic Protein Bcl-2 and Prevents Cellular Apoptosis

Suryakant K. Niture et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Add to Collection

Review Ophthalmology

Mitochondrial Dysfunction in Retinal Diseases

Megha Barot et al.

CURRENT EYE RESEARCH (2011)

Add to Collection

Article Clinical Neurology

Idebenone as a novel, therapeutic approach for Duchenne muscular dystrophy: Results from a 12 month, double-blind, randomized placebo-controlled trial

Gunnar M. Buyse et al.

NEUROMUSCULAR DISORDERS (2011)

Add to Collection

Article Multidisciplinary Sciences

NQO1-Dependent Redox Cycling of Idebenone: Effects on Cellular Redox Potential and Energy Levels

Roman H. Haefeli et al.

PLOS ONE (2011)

Add to Collection

Article Cell Biology

Control of mitochondrial apoptosis by the Bcl-2 family

Joslyn K. Brunelle et al.

JOURNAL OF CELL SCIENCE (2009)

Add to Collection

Article Biochemistry & Molecular Biology

The contribution of DNA repair and antioxidants in determining cell type-specific resistance to oxidative stress

Stuart G. Jarrett et al.

FREE RADICAL RESEARCH (2006)

Add to Collection

Review Genetics & Heredity

Role of mitochondrial DNA in toxic responses to oxidative stress

B Van Houten et al.

DNA REPAIR (2006)

Add to Collection

Review Physiology

The retinal pigment epithelium in visual function

O Strauss

PHYSIOLOGICAL REVIEWS (2005)

Add to Collection

Article Biochemistry & Molecular Biology

Nrf2, a multi-organ protector?

JM Lee et al.

FASEB JOURNAL (2005)

Add to Collection

Review Biochemistry & Molecular Biology

Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation

M Kobayashi et al.

ANTIOXIDANTS & REDOX SIGNALING (2005)

Add to Collection

Article Biochemistry & Molecular Biology

Quinone analogues regulate mitochondrial substrate competitive oxidation

JJ Brière et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)

Add to Collection

Article Pharmacology & Pharmacy

Safety and efficacy of idebenone versus tacrine in patients with Alzheimer's disease: results of a randomized, double-blind, parallel-group multicenter study

H Gutzmann et al.

PHARMACOPSYCHIATRY (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.