Journal
BIOMEDICINES
Volume 9, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines9111680
Keywords
gastric microbiota; gastric carcinogenesis; gastric dysbiosis; non-H. pylori commensals; microbiota-related carcinogenesis; diagnostic biomarker
Categories
Funding
- National Key R&D Program of China [2020YFA0509200/2020YFA0509203]
- RGC Theme-based Res Scheme Hong Kong [T21-705/20-N]
- RGC Collaborative Research Fund [C4039-19GF, C7065-18GF]
- RGC-GRF Hong Kong [14163817]
- Vice Chancellor's Discretionary Fund Chinese University of Hong Kong
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Gastric cancer is a leading cause of cancer death globally, with Helicobacter pylori being a significant risk factor. Recent studies have shown the presence of a large population of microorganisms in the human stomach, with alterations in microbial composition linked to gastric carcinogenesis.
Gastric cancer (GC) is one of the global leading causes of cancer death. The association between Helicobacter pylori, which is a predominant risk factor for GC, with GC development has been well-studied. Recently, accumulating evidence has demonstrated the presence of a large population of microorganisms other than H. pylori in the human stomach. Existing sequencing studies have revealed microbial compositional and functional alterations in patients with GC and highlighted a progressive shift in the gastric microbiota in gastric carcinogenesis with marked enrichments of oral or intestinal commensals. Moreover, using a combination of gastric bacterial signatures, GC patients could be significantly distinguished from patients with gastritis. These findings, therefore, emphasize the importance of a collective microbial community in gastric carcinogenesis. Here, we provide an overview of non-H. pylori gastric microbes in gastric carcinogenesis. The molecular mechanisms of gastric microbes-related carcinogenesis and potential clinical applications of gastric microbiota as biomarkers of GC are also explored.
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