Journal
BIOMEDICINES
Volume 9, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines9111734
Keywords
extracellular vesicles; brain targeting; drug delivery; neurological disorders; brain barriers
Categories
Funding
- Special Research Fund (BOF) of Ghent University
- Foundation for Alzheimer's Research (SAO-FRA)
- VIB
- Baillet Latour Fund
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Extracellular vesicles (EVs) show promise in treating central nervous system (CNS) pathologies as they can cross the CNS barriers. Research focuses on the targeted therapeutic efficacy of EVs from different sources and the vesicular transport mechanisms across CNS barriers, providing a theoretical basis for the application of EVs in brain drug delivery systems.
The treatment of central nervous system (CNS) pathologies is severely hampered by the presence of tightly regulated CNS barriers that restrict drug delivery to the brain. An increasing amount of data suggests that extracellular vesicles (EVs), i.e., membrane derived vesicles that inherently protect and transfer biological cargoes between cells, naturally cross the CNS barriers. Moreover, EVs can be engineered with targeting ligands to obtain enriched tissue targeting and delivery capacities. In this review, we provide a detailed overview of the literature describing a natural and engineered CNS targeting and therapeutic efficiency of different cell type derived EVs. Hereby, we specifically focus on peripheral administration routes in a broad range of CNS diseases. Furthermore, we underline the potential of research aimed at elucidating the vesicular transport mechanisms across the different CNS barriers. Finally, we elaborate on the practical considerations towards the application of EVs as a brain drug delivery system.
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