Journal
BIOMEDICINES
Volume 9, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/biomedicines9101347
Keywords
LC and COPD; microRNAs; prooxidants and antioxidants; GSH; inflammatory cytokines; associations between clinical and biological variables
Categories
Funding
- Instituto de Salud Carlos-III, CIBERES, Spanish Ministry of Science and Innovation, Sociedad Espanola de Neumologia y Cirugia Toracica (SEPAR) 2018 [FIS 18/00075]
- Instituto de Salud Carlos-III, CIBERES, Spanish Ministry of Science and Innovation, Sociedad Espanola de Neumologia y Cirugia Toracica (SEPAR) 2020 [FIS 18/00075]
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MicroRNAs and redox imbalance play a role in lung tumorigenesis in COPD patients. This study found differential expression profiles of microRNAs in LC patients, as well as increased plasma oxidative stress levels and decreased GSH in LC patients with COPD. These systemic alterations may contribute to the pathogenesis of tumorigenesis in these patients.
Lung cancer (LC) risk increases in patients with chronic respiratory diseases (COPD). MicroRNAs and redox imbalance are involved in lung tumorigenesis in COPD patients. Whether systemic alterations of those events may also take place in LC patients remains unknown. Our objectives were to assess the plasma levels of microRNAs, redox balance, and cytokines in LC patients with/without COPD. MicroRNAs (RT-PCR) involved in LC, oxidized DNA, MDA-protein adducts, GSH, TEAC, VEGF, and TGF-beta (ELISA) were quantified in plasma samples from non-LC controls (n = 45), LC-only patients (n = 32), and LC-COPD patients (n = 91). In LC-COPD patients compared to controls and LC-only, MDA-protein adduct levels increased, while those of GSH decreased, and two patterns of plasma microRNA were detected. In both LC patient groups, miR-451 expression was downregulated, while those of microRNA-let7c were upregulated, and levels of TEAC and TGF-beta increased compared to the controls. Correlations were found between clinical and biological variables. A differential expression profile of microRNAs was detected in patients with LC. Moreover, in LC patients with COPD, plasma oxidative stress levels increased, whereas those of GSH declined. Systemic oxidative and antioxidant markers are differentially expressed in LC patients with respiratory diseases, thus implying its contribution to the pathogenesis of tumorigenesis in these patients.
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