4.7 Review

Structures and biological functions of zinc finger proteins and their roles in hepatocellular carcinoma

Journal

BIOMARKER RESEARCH
Volume 10, Issue 1, Pages -

Publisher

BMC
DOI: 10.1186/s40364-021-00345-1

Keywords

Zinc finger protein; Transcription factor; Hepatocellular carcinoma; Transcription regulation; Biological function

Ask authors/readers for more resources

Zinc finger proteins, characterized by their different DNA binding motifs, play a significant role in gene regulation. In hepatocellular carcinoma (HCC), zinc finger proteins exhibit diverse functions in tumorigenesis and progression, and they are also of great significance in HCC diagnosis and prognostic evaluation.
Zinc finger proteins are transcription factors with the finger domain, which plays a significant role in gene regulation. As the largest family of transcription factors in the human genome, zinc finger (ZNF) proteins are characterized by their different DNA binding motifs, such as C2H2 and Gag knuckle. Different kinds of zinc finger motifs exhibit a wide variety of biological functions. Zinc finger proteins have been reported in various diseases, especially in several cancers. Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated death worldwide, especially in China. Most of HCC patients have suffered from hepatitis B virus (HBV) and hepatitis C virus (HCV) injection for a long time. Although the surgical operation of HCC has been extremely developed, the prognosis of HCC is still very poor, and the underlying mechanisms in HCC tumorigenesis are still not completely understood. Here, we summarize multiple functions and recent research of zinc finger proteins in HCC tumorigenesis and progression. We also discuss the significance of zinc finger proteins in HCC diagnosis and prognostic evaluation.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available