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AUTOPHAGY (2015)
Mammalian lipoxygenases and their biological relevance
Hartmut Kuhn et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2015)
Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage
Carolina Brandstetter et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2015)
Investigating Mitochondria as a Target for Treating Age-Related Macular Degeneration
Marcia R. Terluk et al.
JOURNAL OF NEUROSCIENCE (2015)
Protective effect of autophagy on human retinal pigment epithelial cells against lipofuscin fluorophore A2E: implications for age-related macular degeneration
J. Zhang et al.
CELL DEATH & DISEASE (2015)
NLRP3 Inflammasome and Pathobiology in AMD
Lucia Celkova et al.
JOURNAL OF CLINICAL MEDICINE (2015)
Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo
Nadine Jetten et al.
ANGIOGENESIS (2014)
Cytochrome P450 2C8 ω3-Long-Chain Polyunsaturated Fatty Acid Metabolites Increase Mouse Retinal Pathologic Neovascularization-Brief Report
Zhuo Shao et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)
Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD
Sayak K. Mitter et al.
AUTOPHAGY (2014)
Carboxyethylpyrrole plasma biomarkers in age-related macular degeneration
D. Ardeljan et al.
DRUGS OF THE FUTURE (2014)
Angiotensin II type 1 receptor blockade suppresses light-induced neural damage in the mouse retina
Toshio Narimatsu et al.
FREE RADICAL BIOLOGY AND MEDICINE (2014)
REV-ERB and ROR nuclear receptors as drug targets
Douglas J. Kojetin et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Regarding Macular Xanthophylls and ω-3 Long-Chain Polyunsaturated Fatty Acids in Age-Related Macular Degeneration
Katherine A. Meagher et al.
JAMA OPHTHALMOLOGY (2014)
Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E
Khandakar A. S. M. Saadat et al.
FEBS OPEN BIO (2014)
Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis
Wan Ling Wong et al.
LANCET GLOBAL HEALTH (2014)
Protective and Antioxidant Effects of PPARα in the Ischemic Retina
Elizabeth Moran et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2014)
Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration
Kai Kaarniranta et al.
AUTOPHAGY (2013)
Decreased membrane complement regulators in the retinal pigmented epithelium contributes to age-related macular degeneration
Katayoon B. Ebrahimi et al.
JOURNAL OF PATHOLOGY (2013)
Oral Docosahexaenoic Acid in the Prevention of Exudative Age-Related Macular Degeneration The Nutritional AMD Treatment 2 Study
Eric H. Souied et al.
OPHTHALMOLOGY (2013)
12/15-Lipoxygenase-Derived Lipid Metabolites Induce Retinal Endothelial Cell Barrier Dysfunction: Contribution of NADPH Oxidase
Amira Othman et al.
PLOS ONE (2013)
DNA Sequence Variants in PPARGC1A, a Gene Encoding a Coactivator of the ω-3 LCPUFA Sensing PPAR-RXR Transcription Complex, Are Associated with NV AMD and AMD-Associated Loci in Genes of Complement and VEGF Signaling Pathways
John Paul SanGiovanni et al.
PLOS ONE (2013)
NLRP3 Inflammasome Activation in Retinal Pigment Epithelial Cells by Lysosomal Destabilization: Implications for Age-Related Macular Degeneration
Wen Allen Tseng et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2013)
DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88
Valeria Tarallo et al.
CELL (2012)
Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis
Kenichi Shimada et al.
IMMUNITY (2012)
Lipid Composition of the Human Eye: Are Red Blood Cells a Good Mirror of Retinal and Optic Nerve Fatty Acids?
Niyazi Acar et al.
PLOS ONE (2012)
Interleukin-1β Inhibition Prevents Choroidal Neovascularization and Does Not Exacerbate Photoreceptor Degeneration
Sophie Lavalette et al.
AMERICAN JOURNAL OF PATHOLOGY (2011)
Dietary ω-3 Fatty Acid and Fish Intake and Incident Age-Related Macular Degeneration in Women
William G. Christen et al.
ARCHIVES OF OPHTHALMOLOGY (2011)
Reducing the Genetic Risk of Age-Related Macular Degeneration With Dietary Antioxidants, Zinc, and ω-3 Fatty Acids
Lintje Ho
ARCHIVES OF OPHTHALMOLOGY (2011)
Role of 4-hydroxynonenal in epidermal growth factor receptor-mediated signaling in retinal pigment epithelial cells
Rit Vatsyayan et al.
EXPERIMENTAL EYE RESEARCH (2011)
Retinal pigment epithelial expression of complement regulator CD46 is altered early in the course of geographic atrophy
Susan D. Vogt et al.
EXPERIMENTAL EYE RESEARCH (2011)
Docosahexaenoic acid attenuates VCAM-1 expression and NF-κB activation in TNF-α-treated human aortic endothelial cells
Tzu-Ming Wang et al.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2011)
5-Lipoxygenase Metabolite 4-HDHA Is a Mediator of the Antiangiogenic Effect of ω-3 Polyunsaturated Fatty Acids
Przemyslaw Sapieha et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
Long-chain and very long-chain polyunsaturated fatty acids in ocular aging and age-related macular degeneration
Aihua Liu et al.
JOURNAL OF LIPID RESEARCH (2010)
Cytochrome P450-dependent metabolism of omega-6 and omega-3 long-chain polyunsaturated fatty acids
Cosima Arnold et al.
PHARMACOLOGICAL REPORTS (2010)
Inhibition of Cytokine Signaling in Human Retinal Endothelial Cells through Downregulation of Sphingomyelinases by Docosahexaenoic Acid
Madalina Opreanu et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2010)
omega-3 Long-Chain Polyunsaturated Fatty Acid Intake Inversely Associated With 12-Year Progression to Advanced Age-Related Macular Degeneration
John Paul SanGiovanni et al.
ARCHIVES OF OPHTHALMOLOGY (2009)
A2E, a Component of Lipofuscin, Is Pro-Angiogenic In Vivo
Aya Iriyama et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2009)
Nutrition for the Eye: Different Susceptibility of the Retina and the Lacrimal Gland to Dietary Omega-6 and Omega-3 Polyunsaturated Fatty Acid Incorporation
Coralie Schnebelen et al.
OPHTHALMIC RESEARCH (2009)
4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells
Abha Sharma et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2008)
5-lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy
Rose A. Gubitosi-Klug et al.
DIABETES (2008)
Mitochondrial proteomics of the retinal pigment epithelium at progressive stages of age-related macular degeneration
Curtis L. Nordgaard et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2008)
PPARγ activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties
M. Amine Bouhlel et al.
CELL METABOLISM (2007)
Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors
Nicolas G. Bazan
TRENDS IN NEUROSCIENCES (2006)
Drusen complement components C3a and C5a promote choroidal neovascularization
M Nozaki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Anti-inflammatory effect of docosahexaenoic acid on cytokine-induced adhesion molecule expression in human retinal vascular endothelial cells
WQ Chen et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2005)
Role of complement and complement membrane attack complex in laser-induced choroidal neovascularization
PS Bora et al.
JOURNAL OF IMMUNOLOGY (2005)
Eicosapentaenoic acid prevents LPS-induced TNF-α expression by preventing NF-κB activation
Y Zhao et al.
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION (2004)