4.6 Article

Investigation of 1, 3, 4 Oxadiazole Derivative in PTZ-Induced Neurodegeneration: A Simulation and Molecular Approach

Related references

Note: Only part of the references are listed.
Article Neurosciences

Structure-Guided Computational Methods Predict Multiple Distinct Binding Modes for Pyrazoloquinolinones in GABAA Receptors

Jure Fabjan et al.

Summary: Pyrazoloquinolinones (PQs) are a versatile class of GABA(A) receptor ligands that can interact with distinct binding sites on different receptor subtypes, displaying specific functional selectivity. The interaction of PQs with binding sites occurs with diverse binding modes, similar to their interactions with etomidate and barbiturates. Developing improved ligands for these receptors requires consideration of a complex structure-activity landscape with branches between derivative sub-series.

FRONTIERS IN NEUROSCIENCE (2021)

Article Oncology

Molecular Docking, Antioxidant, Anticancer and Antileishmanial Effects of Newly Synthesized Quinoline Derivatives

Zoonish Malghani et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2020)

Review Chemistry, Medicinal

Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery

Karol Biernacki et al.

PHARMACEUTICALS (2020)

Article Neurosciences

Acteoside Isolated fromColebrookea oppositifoliaSmith Attenuates Epilepsy in Mice Via Modulation of Gamma-Aminobutyric Acid Pathways

Gollapalle Lakshminarayanashastry Viswanatha et al.

NEUROTOXICITY RESEARCH (2020)

Article Pharmacology & Pharmacy

Computational and pharmacological evaluation of stevioside derivatives for antinociceptive and anti-inflammatory potential

Sadaf Ahmad et al.

TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH (2020)

Review Neurosciences

Molecular Mechanism Involved in the Pathogenesis of Early-Onset Epileptic Encephalopathy

Giovanna Vitaliti et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

Article Behavioral Sciences

PTZ-induced seizures in mice require a revised Racine scale

Jan Van Erum et al.

EPILEPSY & BEHAVIOR (2019)

Editorial Material Behavioral Sciences

Individualized epilepsy management: Medicines, surgery, and beyond Introduction

Felix Rosenow et al.

EPILEPSY & BEHAVIOR (2019)

Article Biochemistry & Molecular Biology

Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs

John D. McCorvy et al.

NATURE CHEMICAL BIOLOGY (2018)

Review Neurosciences

Molecular Dynamics Simulation for All

Scott A. Hollingsworth et al.

NEURON (2018)

Article Biochemistry & Molecular Biology

Zerumbone binding to estrogen receptors: an in-silico investigation

Eltayeb E. M. Eid et al.

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2018)

Article Integrative & Complementary Medicine

Anticonvulsant Effects of Aerial Parts of Verbena officinalis Extract in Mice: Involvement of Benzodiazepine and Opioid Receptors

Amir Rashidian et al.

JOURNAL OF EVIDENCE-BASED INTEGRATIVE MEDICINE (2017)

Review Clinical Neurology

The Role of Benzodiazepines in the Treatment of Epilepsy

Juan G. Ochoa et al.

CURRENT TREATMENT OPTIONS IN NEUROLOGY (2016)

Article Chemistry, Medicinal

Design, synthesis, pharmacological evaluation, and docking study of new acridone-based 1,2,4-oxadiazoles as potential anticonvulsant agents

Maryam Mohammadi-Khanaposhtani et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2016)

Article Pharmacology & Pharmacy

Anticonvulsant, Anxiolytic, and Sedative Activities of Verbena officinalis

Abdul Waheed Khan et al.

FRONTIERS IN PHARMACOLOGY (2016)

Review Pharmacology & Pharmacy

Candidate Drug Targets for Prevention or Modification of Epilepsy

Nicholas H. Varvel et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55 (2015)

Article Chemistry, Medicinal

Potent acetylcholinesterase inhibitors: Design, synthesis, biological evaluation, and docking study of acridone linked to 1,2,3-triazole derivatives

Maryam Mohammadi-Khanaposhtani et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

Review Neurosciences

Adult hippocampal neurogenesis and its role in Alzheimer's disease

Yangling Mu et al.

MOLECULAR NEURODEGENERATION (2011)

Review Clinical Neurology

Adverse effects of antiepileptic drugs: a brief overview of important issues

Joyce A. Cramer et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2010)

Article Immunology

Anti-inflammatory effect of lucidone in mice via inhibition of NF-κB/MAP kinase pathway

K. J. Senthil Kumar et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2010)

Article Neurosciences

Neuroinflammation in Alzheimer's disease and prion disease

P Eikelenboom et al.

Review Biochemistry & Molecular Biology

Molecular dynamics simulations of biomolecules

M Karplus et al.

NATURE STRUCTURAL BIOLOGY (2002)

Article Clinical Neurology

GABAergic mechanisms in epilepsy

DM Treiman

EPILEPSIA (2001)

Review Geriatrics & Gerontology

Inflammation and Alzheimer's disease

H Akiyama et al.

NEUROBIOLOGY OF AGING (2000)