Journal
JOURNAL OF INFLAMMATION RESEARCH
Volume 15, Issue -, Pages 409-422Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/JIR.S344071
Keywords
NLRP3 inflammasome; Glycyrrhiza; inflammatory diseases; anti-inflammatory
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Funding
- National Natural Science Foundation of China [81874368, 81630100, 81721002]
- Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine [ZYYCXTD-C-202005]
- National Science & Technology Major Project Key New Drug Creation and Manufacturing Program [2017ZX09301022, 2018ZX09101002-001-002]
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This article summarizes the role and mechanism of active ingredients such as licochalcone A, echinatin, isoliquiritigenin, and glycyrrhizin in Glycyrrhiza in targeting the NLRP3 inflammasome and treating related inflammatory diseases.
Inflammation is the tissues' defense response after the body is stimulated by microbial infection or damage signals, and it is initiated when pattern recognition receptors recognize pathogen-related molecular patterns and danger-related molecular patterns. The hyperactivation of NLRP3 inflammasome, the main driving force of immune outbreaks, is involved in a wide range of inflammatory diseases. Meanwhile, growing evidence has indicated that the development of NLRP3-targeted therapies offers great potential and promise for the treatment of related diseases. The search for and development of efficacious anti-inflammatory prodrugs from natural sources of plants and traditional Chinese medicines (TCMs) have received extensive attention. Glycyrrhiza, an important minister in the kingdom of TCMs, has high activity and a wide range of therapeutic effects. Studies have shown that a variety of active components found in Glycyrrhiza, such as licochalcone A, echinatin, isoliquiritigenin, and glycyrrhizin, produce a wide range of anti-inflammatory effects by discouraging NLRP3 inflammasome activation. Here, we summarize the role and mechanism of the active ingredients in Glycyrrhiza that target the NLRP3 inflammasome and treat related inflammatory diseases. We describe a favorable approach for the development of natural, safe, and efficient drugs that exploit these naturally occurring active ingredients to treat NLRP3-driven diseases.
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