4.6 Review

Novel Insights into the Emerging Role of Neat1 and Its Effects Downstream in the Regulation of Inflammation

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

NEAT1 Decreasing Suppresses Parkinson's Disease Progression via Acting as miR-1301-3p Sponge

Qiang Sun et al.

Summary: Our study demonstrated that decreasing NEAT1 effectively suppressed MPP+-induced neuronal apoptosis. Mechanistically, downregulation of NEAT1 repressed alpha-syn-induced activation of NLRP3 inflammasome via inhibiting the expression of GJB1 by targeting miR-1301-3p. This provides new evidence for lncRNA NEAT1 as a potential therapeutic target for Parkinson's disease.

JOURNAL OF MOLECULAR NEUROSCIENCE (2021)

Article Biochemistry & Molecular Biology

NEAT1 polyA-modulating antisense oligonucleotides reveal opposing functions for both long non-coding RNA isoforms in neuroblastoma

Alina Naveed et al.

Summary: Numerous lncRNAs, including NEAT1, are dysregulated in cancer and are considered therapeutic targets. Researchers have developed ASOs targeting NEAT1_1 to increase NEAT1_2 expression and paraspeckle abundance in neuroblastoma cells, leading to a decrease in cell viability in high-risk neuroblastoma. Furthermore, altering lncRNA polyadenylation events using ASOs shows potential as an anti-cancer strategy.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Article Immunology

Quercetin inhibits caerulein-induced acute pancreatitis through regulating miR-216b by targetingMAP2K6andNEAT1

Bo Sheng et al.

Summary: Quercetin can alleviate inflammation in acute pancreatitis by up-regulating miR-216b, inhibiting the p38/MAPK signaling pathway, and positively affecting inflammatory mediators.

INFLAMMOPHARMACOLOGY (2021)

Article Neurosciences

Deficiency of NEAT1 prevented MPP+-induced inflammatory response, oxidative stress and apoptosis in dopaminergic SK-N-SH neuroblastoma cells via miR-1277-5p/ARHGAP26 axis

Shufang Zhou et al.

Summary: Noncoding RNAs, specifically NEAT1, play a significant role in MPP+-induced neurotoxicity by regulating miR-1277-5p and ARHGAP26; the upregulation of NEAT1 may contribute to neuron injury induced by MPP+ through the NEAT1-miR-1277-5p-ARHGAP26 ceRNA pathway.

BRAIN RESEARCH (2021)

Article Neurosciences

Peripheral inflammation and blood-brain barrier disruption: effects and mechanisms

Xiaowen Huang et al.

Summary: The blood-brain barrier is a crucial physiological barrier that separates the central nervous system from the peripheral circulation. Disruption of the BBB by peripheral inflammation can lead to various CNS diseases.

CNS NEUROSCIENCE & THERAPEUTICS (2021)

Article Medicine, Research & Experimental

lncRNA NEAT1 ameliorates LPS-induced inflammation in MG63 cells by activating autophagy and suppressing the NLRP3 inflammasome

Wenyu Dai et al.

Summary: The study found that stimulation of MG63 cells with LPS led to downregulation of NEAT1, increase in expression of inflammatory cytokines, inhibition of autophagy and osteogenesis-related proteins, promotion of apoptosis, and alteration of the cell cycle.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

Article Biochemistry & Molecular Biology

LncRNA Snhg8 attenuates microglial inflammation response and blood-brain barrier damage in ischemic stroke through regulating miR-425-5p mediated SIRT1/NF-κB signaling

Jianan Tian et al.

Summary: Studies have shown that abnormal expressed long noncoding RNA (lncRNA) such as Snhg8 plays a crucial role in ischemic stroke by modulating microglial inflammation and brain-blood barrier damage. The competitive endogenous RNA mechanism of Snhg8 in regulating the miR-425-5p/SIRT1/NF-kappa B pathway is essential for understanding the pathogenesis of cerebral ischemia.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY (2021)

Article Immunology

被撤回的出版物: LncRNA NEAT1 participates in inflammatory response in macrophages infected by mycobacterium tuberculosis through targeted regulation of miR-377-3p (Retracted article. See vol. 165, 2022)

Qin Sun et al.

Summary: NEAT1 is highly expressed in patients with pulmonary TB, while miR-377-3p is poorly expressed. The concentrations of inflammatory factors in the serum of TB patients are significantly higher compared to healthy individuals. Inhibition of NEAT1 and increase of miR-377-3p can reduce inflammatory factors and cell proliferation, and increase the rate of apoptosis.

MICROBIAL PATHOGENESIS (2021)

Review Clinical Neurology

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

Fangda Leng et al.

Summary: Microglial activation and neuroinflammation play important roles in Alzheimer's disease, affecting disease progression and pathologies. Current research focuses on the interplay between neuroinflammation and amyloid and tau pathologies, with a specific interest in modulating microglia as a therapeutic strategy for AD.

NATURE REVIEWS NEUROLOGY (2021)

Article Biochemistry & Molecular Biology

LncRNA NEAT1 Regulates the Development of Parkinson's Disease by Targeting AXIN1 Via Sponging miR-212-3p

Tao Liu et al.

Summary: NEAT1 is highly expressed in PD, and knockdown of NEAT1 can promote cell viability and suppress PD progression through the miR-212-3p/AXIN1 pathway.

NEUROCHEMICAL RESEARCH (2021)

Article Cell Biology

LncRNA NEAT1 regulates the proliferation and production of the inflammatory cytokines in rheumatoid arthritis fibroblast-like synoviocytes by targeting miR-204-5p

Jianwei Xiao et al.

Summary: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by erosive arthritis, which can lead to joint dysfunction and malformations. Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) play important roles in RA, with lncRNA NEAT1 identified as a potential diagnostic and therapeutic target in this disease. The study found that NEAT1 was up-regulated in RA patients' synovial tissue and TNF-alpha treated RA-FLSs, suggesting its potential as a therapeutic target for RA patients.

HUMAN CELL (2021)

Review Neurosciences

NEAT1 on the Field of Parkinson's Disease: Offense, Defense, or a Player on the Bench?

Fanni Annamaria Boros et al.

Summary: Parkinson's disease is the second most common neurodegenerative disease globally, and there is a need to identify biomarkers and new therapeutic targets. NEAT1 has emerged as a possible regulatory hub in PD development, but its exact role is still debated. The contradictory findings of NEAT1's involvement in PD highlight the complexity of neurodegenerative disorders and the limitations of disease models, calling for further research to clarify its potential as a biomarker and therapeutic target.

JOURNAL OF PARKINSONS DISEASE (2021)

Review Physiology

Inflammation in Periodontal Disease: Possible Link to Vascular Disease

Oindrila Paul et al.

Summary: Inflammation is a protective response that can either lead to tissue healing or pathological processes. Periodontal disease initiated by bacteria triggers inflammatory responses that can result in tissue loss. Inflammation may also be associated with conditions like diabetes and cardiovascular disease.

FRONTIERS IN PHYSIOLOGY (2021)

Article Genetics & Heredity

Downregulated microRNA-129-5p by Long Non-coding RNA NEAT1 Upregulates PEG3 Expression to Aggravate Non-alcoholic Steatohepatitis

Zhi Zhang et al.

Summary: NEAT1 can specifically bind to miR-129-5p to regulate the activation of HSCs, presenting a promising therapeutic strategy for treating NASH.

FRONTIERS IN GENETICS (2021)

Review Medicine, Research & Experimental

The critical roles of lncRNAs in the development of osteosarcoma

Soudeh Ghafouri-Fard et al.

Summary: Osteosarcoma is a rare malignancy in children and adolescents, and understanding the underlying mechanisms of its evolution is crucial for improving management. Abnormal regulation of long non-coding RNAs has been observed in osteosarcoma, with various lncRNAs identified as potential targets for novel therapeutic approaches. Increasing research is focusing on utilizing lncRNAs to develop advanced treatments for osteosarcoma.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Biochemistry & Molecular Biology

NEAT1/hsa-miR-372?3p axis participates in rapamycin-induced lipid metabolic disorder

Guanghan Fan et al.

Summary: This study investigates the mechanism of rapamycin-induced dyslipidemia after liver transplantation by focusing on the role of microRNA hsa-miR-372?3p in regulating triglyceride metabolism through target genes AGPS and APOC4. The results suggest that the NEAT1/hsa-miR-372?3p/AGPS/APOC4 axis plays a crucial role in disrupting lipid homeostasis caused by rapamycin, providing a potential therapeutic target for combating dyslipidemia post-LT.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Article Cell Biology

LncRNA NEAT1 Promotes Inflammatory Response in Sepsis via the miR-31-5p/POU2F1 Axis

Yang Yang et al.

Summary: NEAT1 inhibits the progression of sepsis induced by LPS in RAW264.7 cells by modulating the miR-31-5p/POU2F1 axis, suggesting NEAT1 as a potential therapeutic target for sepsis.

INFLAMMATION (2021)

Article Medicine, Research & Experimental

Lnc-NEAT1 induces cell apoptosis and inflammation but inhibits proliferation in a cellular model of hepatic ischemia/reperfusion injury

Liu Wang et al.

Summary: The study revealed that overexpression of lnc-NEAT1 in hepatic ischemia/reperfusion injury model induced cell apoptosis and inflammation while inhibiting cell proliferation. Targeted interference of lnc-NEAT1 can reduce apoptosis rate and inflammatory cytokine expression, promoting liver cell proliferation.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2021)

Article Pharmacology & Pharmacy

被撤回的出版物: LncRNA NEAT1 acts as a key regulator of cell apoptosis and inflammatory response by the miR-944/TRIM37 axis in acute lung injury (Retracted article. See vol. 149, pg. 172, 2022)

Cheng Chen et al.

Summary: The study revealed the important role of TRIM37 in ALI, involving in regulating inflammatory response and cell apoptosis through the NF-κB pathway. In addition, miR-944 and NEAT1 also play crucial roles in this process.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2021)

Article Medicine, General & Internal

The correlation of long non-coding RNA NEAT1 and its targets microRNA (miR)-21, miR-124, and miR-125a with disease risk, severity, and inflammation of allergic rhinitis

Rujuan Wang et al.

Summary: The study revealed a close correlation of lncRNA NEAT1 and its targets miR-21 and miR-125a with disease risk, severity, and inflammation of allergic rhinitis, suggesting their potential as biomarkers for AR assessment.

MEDICINE (2021)

Article Biochemistry & Molecular Biology

Gastrodin Alleviates Cerebral Ischaemia/Reperfusion Injury by Inhibiting Pyroptosis by Regulating the lncRNA NEAT1/miR-22-3p Axis

Heng-Sheng Zhang et al.

Summary: The study revealed that Gastrodin (GAS) significantly improved neurological scores and reduced cerebral infarction area in rats by modulating the lncRNA NEAT1/miR-22-3p axis. GAS inhibited pyroptosis by downregulating NLRP3, inflammatory factors (IL-1 beta, IL-18), and cleaved caspase-1. Furthermore, GAS attenuated I/R-induced inflammation in neuronal cells through the modulation of the lncRNA NEAT1/miR-22-3p axis.

NEUROCHEMICAL RESEARCH (2021)

Review Multidisciplinary Sciences

TNF receptor-associated factor 6 (TRAF6) plays crucial roles in multiple biological systems through polyubiquitination-mediated NF-κB activation

Mizuki Yamamoto et al.

Summary: NF-kappa B is a transcription factor that plays crucial roles in cell proliferation, differentiation, and apoptosis, as well as in various physiological processes such as development, organogenesis, immunity, inflammation, and neurological functions. TRAF family proteins are key players in the signaling pathways activating NF-kappa B, revealing the significance of ubiquitin in NF-kappa B signaling and other biological systems. The discovery of the nonproteolytic functions of ubiquitin in cellular signaling has revolutionized the field of ubiquitin studies.

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES (2021)

Article Oncology

LncRNA NEAT1 mediates intestinal inflammation by regulating TNFRSF1B

Shiyu Pan et al.

Summary: The study demonstrates that NEAT1 is involved in the development of inflammatory bowel disease by regulating the expression of TNFRSF1B and promoting the translocation of NF-kB p65, which mediates intestinal inflammation.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Review Medicine, Research & Experimental

The progress, prospects, and challenges of the use of non-coding RNA for diabetic wounds

Jianyi Li et al.

Summary: This article discusses the role and challenges of non-coding RNA in chronic diabetic wounds, providing insights into new diagnostic and treatment strategies.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

Review Immunology

NF-κB: At the Borders of Autoimmunity and Inflammation

Laura Barnabei et al.

Summary: NF-kappa B transcription factor plays a crucial role in regulating various aspects of innate and adaptive immune functions, serving as a key mediator of immune homeostasis. It is involved in central and peripheral tolerance, as well as the inactivation and destruction of autoreactive immune cells, contributing to immune tolerance. Furthermore, NF-kappa B plays a role in the pathogenesis of autoimmune diseases and has informed new therapeutic approaches for treating these conditions.

FRONTIERS IN IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Microglia promote autoimmune inflammation via the noncanonical NF-κB pathway

Zuliang Jie et al.

Summary: Microglia play a critical role in the progression of EAE by mediating noncanonical NF-κB signaling pathway, with NIK being essential for the recruitment of inflammatory T cells and monocytes in the CNS. The activation of T cell-derived cytokines and chemokines is important for the second-wave of T cell recruitment and disease progression in EAE.

SCIENCE ADVANCES (2021)

Review Cell & Tissue Engineering

Modulating poststroke inflammatory mechanisms: Novel aspects of mesenchymal stem cells, extracellular vesicles and microglia

Wen-Qiang Xin et al.

Summary: Inflammation and microglia play crucial roles in the pathological process of ischemic stroke. Altering activation state of microglia is an intriguing therapeutic strategy, and MSCs and MSC-derived EVs have been shown to regulate inflammation and tissue repair under preclinical stroke conditions. However, the exact mechanisms of these interactions remain unclear.

WORLD JOURNAL OF STEM CELLS (2021)

Article Immunology

Transcriptome-Wide Analysis to Identify the Inflammatory Role of lncRNA Neatl in Experimental Ischemic Stroke

Fa Jin et al.

Summary: Ischemic stroke is a major cause of mortality and disability globally, with secondary neuroinflammation exacerbating injury. This study identified inflammation-associated lncRNA Neatl as a potential therapeutic target for ischemic stroke by analyzing differentially expressed genes and conducting in vivo experiments. Knockdown of Neatl significantly reduced brain damage by inhibiting activation of microglia and their release of proinflammatory cytokines.

JOURNAL OF INFLAMMATION RESEARCH (2021)

Review Immunology

Emerging Role of LncRNAs in Ischemic Stroke- Novel Insights into the Regulation of Inflammation

Yongli Pan et al.

Summary: This review summarizes the therapeutic effects and action mechanisms of long noncoding RNAs (lncRNAs) on ischemia by regulating inflammation and microglial activation, especially in the context of neuroinflammation in ischemic stroke. Studies have shown that lncRNAs have the potential to modulate inflammation by inhibiting and activating various signaling pathways, such as microRNAs, NF-kappa B, and ERK.

JOURNAL OF INFLAMMATION RESEARCH (2021)

Article Immunology

LncRNA NEAT1 Promote Inflammatory Responses in Coronary Slow Flow Through Regulating miR-148b-3p/ICAM-1 Axis

Qing Zhu et al.

Summary: This study demonstrates the independent predictive value of plasma sICAM-1, miR-148b-3p, and NEAT1 for the diagnosis of CSF. NEAT1 functions as a competing endogenous RNA to regulate ICAM-1 expression in the progression of the disease.

JOURNAL OF INFLAMMATION RESEARCH (2021)

Article Medicine, General & Internal

Role of NEAT1/MiR-9-5p/SLC26A2 Pathway on Human Airway Smooth Muscle Cell

Xiangying Wang et al.

Summary: The study revealed significant upregulation of SLC26A2 in asthma-related samples, and NEAT1-mediated regulation of miRNA and LncRNA influenced the biological function of PDGF-induced HASMCs, highlighting potential therapeutic targets for asthma.

YONSEI MEDICAL JOURNAL (2021)

Review Biochemistry & Molecular Biology

Inflammation and tumor progression: signaling pathways and targeted intervention

Huakan Zhao et al.

Summary: Inflammation plays a crucial role in cancer development and therapy, either promoting or inhibiting tumor progression and therapeutic outcomes. Various signaling pathways and factors have been identified as pivotal regulators of inflammation initiation and resolution.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Review Immunology

Prostanoids and Resolution of Inflammation - Beyond the Lipid-Mediator Class Switch

Tobias Schmid et al.

Summary: Bioactive lipid mediators, such as prostanoids and specialized pro-resolving mediators, play key roles in regulating inflammatory processes. While prostanoids are known for their pro-inflammatory properties, they also contribute to the resolution of inflammation and return to homeostasis. Further research on the resolution-regulatory properties of prostanoids may have implications for anti-inflammatory therapeutic interventions targeting these lipid mediators.

FRONTIERS IN IMMUNOLOGY (2021)

Article Biotechnology & Applied Microbiology

Knockdown of long non-coding RNA NEAT1 relieves the inflammatory response of spinal cord injury through targeting miR-211-5p/MAPK1 axis

Qing An et al.

Summary: The study demonstrated that NEAT1 plays a key role in inflammation of spinal cord injury, and its effects were mediated through the miR-211-5p/MAPK1 axis to regulate cell apoptosis rate and viability.

BIOENGINEERED (2021)

Review Cell Biology

Chronic peripheral inflammation: a possible contributor to neurodegenerative diseases

Patrick Suss et al.

Summary: The contribution of chronic peripheral inflammation to the pathogenesis of age-related neurodegenerative diseases is an outstanding question, with a focus on microglia, the resident immune cells of the brain parenchyma. There is an ongoing debate on whether peripheral immune cells have the potential to migrate into the brain under certain permissive circumstances.

NEURAL REGENERATION RESEARCH (2021)

Article Biotechnology & Applied Microbiology

Long non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) sponges microRNA-124-3p to up-regulate phosphodiesterase 4B (PDE4B) to accelerate the progression of Parkinson's disease

Ming-Yu Chen et al.

Summary: The study demonstrated that depletion of NEAT1 in Parkinson's disease cell models increased cell viability, reduced cell injury and inflammatory response by regulating the expression levels of miR-124-3p and PDE4B. NEAT1 was identified as a promising target for treating PD.

BIOENGINEERED (2021)

Review Biochemistry & Molecular Biology

NEAT1 as a competing endogenous RNA in tumorigenesis of various cancers: Role, mechanism and therapeutic potential

Kun Li et al.

Summary: NEAT1, a long non-coding RNA upregulated in various human cancer types, plays a crucial role in tumor development by acting as a ceRNA that modulates the expression levels of miRNAs and their target genes. Understanding the molecular mechanisms of NEAT1 in tumorigenesis enhances its potential as a biomarker and target for cancer therapy.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Article Biochemistry & Molecular Biology

MicroRNA-377-3p alleviates IL-1 beta-caused chondrocyte apoptosis and cartilage degradation in osteoarthritis in part by downregulating ITGA6

Yihui Tu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Medicine, General & Internal

NEAT1 promotes LPS-induced inflammatory injury in macrophages by regulating miR-17-5p/TLR4

Yanhui Li et al.

OPEN MEDICINE (2020)

Article Medicine, General & Internal

NEAT1 aggravates sepsis-induced acute kidney injury by sponging miR-22-3p

Yawei Feng et al.

OPEN MEDICINE (2020)

Article Biochemistry & Molecular Biology

LncRNA NEAT1 regulated inflammation and apoptosis in a rat model of sepsis-induced acute kidney injury via MiR-27a-3p/TAB3 axis

Jiasheng Wang et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Long Noncoding RNAs and Circular RNAs in Autoimmune Diseases

Valeria Lodde et al.

BIOMOLECULES (2020)

Review Immunology

Modulation of Chronic Inflammation by Quercetin: The Beneficial Effects on Obesity

Shin Sato et al.

JOURNAL OF INFLAMMATION RESEARCH (2020)

Review Gastroenterology & Hepatology

LncRNANEAT1: Shedding light on mechanisms and opportunities in liver diseases

Fang-tian Bu et al.

LIVER INTERNATIONAL (2020)

Review Biochemistry & Molecular Biology

Organization and function of paraspeckles

Yang Wang et al.

SPOTLIGHT ON CHINA: RNA (2020)

Article Medicine, Research & Experimental

LncRNA NEAT1 promotes apoptosis and inflammation in LPS-induced sepsis models by targeting miR-590-3p

Lingling Liu et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2020)

Article Medicine, Research & Experimental

LncRNA NEAT1/microRNA-129-5p/SOCS2 axis regulates liver fibrosis in alcoholic steatohepatitis

Junfeng Ye et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

Article Biochemistry & Molecular Biology

Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine

Simeng Wen et al.

MOLECULAR CANCER (2020)

Review Biochemistry & Molecular Biology

LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems?

Elisa Taiana et al.

NON-CODING RNA (2020)

Article Physiology

Long noncoding RNA NEAT1 sponges miR-129 to modulate renal fibrosis by regulation of collagen type I

Chen Li et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2020)

Article Biochemistry & Molecular Biology

NEAT1 contributes to ox-LDL-induced inflammation and oxidative stress in macrophages through inhibiting miR-128

Dou-Dou Chen et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

Review Biochemistry & Molecular Biology

The Implications of the Long Non-Coding RNA NEAT1 in Non-Cancerous Diseases

Felix Prinz et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Cardiac & Cardiovascular Systems

Long noncoding RNA NEAT1 modulates immune cell functions and is suppressed in early onset myocardial infarction patients

Martina Gast et al.

CARDIOVASCULAR RESEARCH (2019)

Article Multidisciplinary Sciences

The lncRNA Neat1 promotes activation of inflammasomes in macrophages

Pengfei Zhang et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Dihydroartemisinin attenuates alcoholic fatty liver through regulation of lipin-1 signaling

Xingran Chen et al.

IUBMB LIFE (2019)

Review Medicine, Research & Experimental

Long Non-coding RNA in CNS Injuries: A New Target for Therapeutic Intervention

Li Zhang et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

Article Immunology

LncRNA NEAT1 promotes inflammatory response in sepsis-induced liver injury via the Let-7a/TLR4 axis

Cui-Cui Zhang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

Review Oncology

Long Non-coding RNA PVT1 as a Prognostic and Therapeutic Target in Pediatric Cancer

Ariadna Boloix et al.

FRONTIERS IN ONCOLOGY (2019)

Review Oncology

Involvement of the long noncoding RNA NEAT1 in carcinogenesis

Christiane Klec et al.

MOLECULAR ONCOLOGY (2019)

Article Biochemistry & Molecular Biology

Chronic inflammation in the etiology of disease across the life span

David Furman et al.

NATURE MEDICINE (2019)

Review Agriculture, Dairy & Animal Science

Inflammation: friend or foe for animal production?

Leon J. Broom et al.

POULTRY SCIENCE (2018)

Article Emergency Medicine

Circulating lncRNA NEAT1 correlates with increased risk, elevated severity and unfavorable prognosis in sepsis patients

Qinghe Huang et al.

AMERICAN JOURNAL OF EMERGENCY MEDICINE (2018)

Article Pharmacology & Pharmacy

Long non-coding RNA NEAT1 mediates the toxic of Parkinson's disease induced by MPTP/MPP plus via regulation of gene expression

Ying Liu et al.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2018)

Review Neurosciences

Microglia and Astrocytes in Alzheimer's Disease: Implications for Therapy

Marc Fakhoury

CURRENT NEUROPHARMACOLOGY (2018)

Review Biochemistry & Molecular Biology

Noncoding RNAs: Master Regulators of Inflammatory Signaling

Chen Li Chew et al.

TRENDS IN MOLECULAR MEDICINE (2018)

Review Cell Biology

Long non-coding RNAs in ischemic stroke

Mei-Hua Bao et al.

CELL DEATH & DISEASE (2018)

Review Chemistry, Analytical

Lipid metabolism in inflammation-related diseases

Cuiping Zhang et al.

ANALYST (2018)

Article Oncology

Neat1-miRNA204-5p-PI3K-AKT axis as a potential mechanism for photodynamic therapy treated colitis in mice

Kunpeng Wang et al.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2018)

Review Genetics & Heredity

Long Non-coding RNA NEAT1: A Novel Target for Diagnosis and Therapy in Human Tumors

Peixin Dong et al.

FRONTIERS IN GENETICS (2018)

Article Physiology

Triglyceride Metabolism in the Liver

Michele Alves-Bezerra et al.

COMPREHENSIVE PHYSIOLOGY (2018)

Article Neurosciences

Altered Expression of the Long Noncoding RNA NEAT1 in Huntington's Disease

Jun-Sang Sunwoo et al.

MOLECULAR NEUROBIOLOGY (2017)

Article Biochemistry & Molecular Biology

NEAT1/miR-181c Regulates Osteopontin (OPN)-Mediated Synoviocyte Proliferation in Osteoarthritis

Qiyuan Wang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2017)

Review Immunology

The non-canonical NF-κB pathway in immunity and inflammation

Shao-Cong Sun

NATURE REVIEWS IMMUNOLOGY (2017)

Review Cell Biology

NEAT1: A novel cancer-related long non-coding RNA

Xin Yu et al.

CELL PROLIFERATION (2017)

Article Cell Biology

Structural, super-resolution microscopy analysis of paraspeckle nuclear body organization

Jason A. West et al.

JOURNAL OF CELL BIOLOGY (2016)

Article Gastroenterology & Hepatology

MicroRNA-124 Promotes Intestinal Inflammation by Targeting Aryl Hydrocarbon Receptor in Crohn's Disease

Ye Zhao et al.

JOURNAL OF CROHNS & COLITIS (2016)

Article Microbiology

Lipid Mediators in Inflammation

Melanie Bennett et al.

MICROBIOLOGY SPECTRUM (2016)

Review Biochemistry & Molecular Biology

Long Non-Coding RNAs as Master Regulators in Cardiovascular Diseases

Krystal Archer et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Review Cardiac & Cardiovascular Systems

Noncoding RNAs in diabetes vascular complications

Cristina Beltrami et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

The mitochondrial lncRNA ASncmtRNA-2 is induced in aging and replicative senescence in Endothelial Cells

Valentina Bianchessi et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

Editorial Material Biochemistry & Molecular Biology

Focus Issue: Inflammatory mechanisms

John F. Foley

SCIENCE SIGNALING (2015)

Review Immunology

New insights into the resolution of inflammation

Derek Gilroy et al.

SEMINARS IN IMMUNOLOGY (2015)

Review Pharmacology & Pharmacy

The critical role of Akt in cardiovascular function

Prasanna Abeyrathna et al.

VASCULAR PHARMACOLOGY (2015)

Editorial Material Biochemistry & Molecular Biology

Focus Issue: Inflammatory mechanisms

John F. Foley

SCIENCE SIGNALING (2015)

Review Immunology

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

Jonathan D. Cherry et al.

JOURNAL OF NEUROINFLAMMATION (2014)

Article Biochemistry & Molecular Biology

The long noncoding RNA Neat1 is required for mammary gland development and lactation

Laura Standaert et al.

Review Immunology

The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer's Disease Brain

Megan M. Varnum et al.

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2012)

Article Multidisciplinary Sciences

Landscape of transcription in human cells

Sarah Djebali et al.

NATURE (2012)

Review Biochemistry & Molecular Biology

The immunology of stroke: from mechanisms to translation

Costantino Iadecola et al.

NATURE MEDICINE (2011)

Review Biochemistry & Molecular Biology

Atherosclerosis: current pathogenesis and therapeutic options

Christian Weber et al.

NATURE MEDICINE (2011)

Review Physiology

Physiology of Microglia

Helmut Kettenmann et al.

PHYSIOLOGICAL REVIEWS (2011)

Review Cell Biology

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

Rong Jin et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2010)

Review Clinical Neurology

Microglial Activation in Stroke: Therapeutic Targets

Midori A. Yenari et al.

NEUROTHERAPEUTICS (2010)

Review Rheumatology

Neutrophil function in inflammation and inflammatory diseases

Helen L. Wright et al.

RHEUMATOLOGY (2010)

Article Biochemistry & Molecular Biology

An Architectural Role for a Nuclear Noncoding RNA: NEAT1 RNA Is Essential for the Structure of Paraspeckles

Christine M. Clemson et al.

MOLECULAR CELL (2009)

Article Multidisciplinary Sciences

MENε/β noncoding RNAs are essential for structural integrity of nuclear paraspeckles

Yasnory T. F. Sasaki et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Review Multidisciplinary Sciences

Origin and physiological roles of inflammation

Ruslan Medzhitov

NATURE (2008)

Article Biotechnology & Applied Microbiology

A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains

John N. Hutchinson et al.

BMC GENOMICS (2007)