4.6 Review

Novel Insights into the Emerging Role of Neat1 and Its Effects Downstream in the Regulation of Inflammation

Journal

JOURNAL OF INFLAMMATION RESEARCH
Volume 15, Issue -, Pages 557-571

Publisher

DOVE MEDICAL PRESS LTD
DOI: 10.2147/JIR.S338162

Keywords

Neat1; inflammation; microglia; lipids; microRNA; NF-kappa B

Categories

Ask authors/readers for more resources

This article reviews the regulation of Neat1 and its modulation of target gene expression, and explores the impact of Neat1 on inflammation, including activation or inhibition of various signaling pathways.
Nuclear paraspeckle assembly transcript 1 (Neat1) located at chromosome 11 is a long non-coding RNA that is widely expressed in mammalian cell types, and which is overexpressed in several inflammation-related disorders. Inflammation implies a plethora of mutual interactions between both soluble factors and cells due to various stimuli including tissue injury. Although there is no doubt that inflammation is critically involved in multiple biological and pathological processes alike, the precise mechanisms being involved are still open for debate. In this context, the role of Neat1 as a regulator of inflammation, microglial activation, and lipid accumulation under various inflammatory conditions remains elusive. Herein, we review the regulation of Neat1 and how it modulates the expression of its target genes. Thereafter, we will review the impact of Neat1 on inflammation by activating or inhibiting various signaling pathways, such as microRNAs, AKT, TLR4, TRAF6, and NF-kappa B.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available