4.5 Article

Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics

Related references

Note: Only part of the references are listed.
Review Endocrinology & Metabolism

Hyperinsulinemia in Obesity, Inflammation, and Cancer

Anni M. Y. Zhang et al.

Summary: This paper discusses the relationship between hyperinsulinemia and consequences such as inflammation, aging, and cancer in the context of metabolic dysfunctions, shedding light on the consequences and mechanisms of excess insulin production and action. By studying the role of hyperinsulinemia in various chronic diseases, there is a potential to identify more effective therapeutic approaches or lifestyle interventions for preventing or treating obesity, diabetes, and cancer. Identifying pertinent questions for future investigation is also a focus.

DIABETES & METABOLISM JOURNAL (2021)

Article Biochemistry & Molecular Biology

Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma

Katherine Minjee Chung et al.

Review Oncology

Hyperinsulinaemia in cancer

Emily J. Gallagher et al.

NATURE REVIEWS CANCER (2020)

Article Biochemistry & Molecular Biology

Comprehensive Integration of Single-Cell Data

Tim Stuart et al.

Letter Cell Biology

Endogenous Hyperinsulinemia Contributes to Pancreatic Cancer Development

Anni M. Y. Zhang et al.

CELL METABOLISM (2019)

Review Gastroenterology & Hepatology

Pancreatic steatosis: an update

Resham Ramkissoon et al.

CURRENT OPINION IN GASTROENTEROLOGY (2019)

Review Cell Biology

Four Decades After the Discovery of Regenerating Islet-Derived (Reg) Proteins: Current Understanding and Challenges

Zijing Chen et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2019)

Review Oncology

Role of Regenerating Islet-Derived Protein 3A in Gastrointestinal Cancer

Meng-ya Zhang et al.

FRONTIERS IN ONCOLOGY (2019)

Article Medicine, Research & Experimental

Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution

Abdel Nasser Hosein et al.

JCI INSIGHT (2019)

Article Biotechnology & Applied Microbiology

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Andrew Butler et al.

NATURE BIOTECHNOLOGY (2018)

Article Endocrinology & Metabolism

Sex differences in insulin and glucagon responses for glucose homeostasis in young healthy Japanese adults

Ichiro Horie et al.

JOURNAL OF DIABETES INVESTIGATION (2018)

Review Endocrinology & Metabolism

A causal role for hyperinsulinemia in obesity

Nicole M. Templeman et al.

JOURNAL OF ENDOCRINOLOGY (2017)

Article Multidisciplinary Sciences

Critical role for arginase 2 in obesity-associated pancreatic cancer

Tamara Zaytouni et al.

NATURE COMMUNICATIONS (2017)

Article Medicine, General & Internal

Murine genotype impacts pancreatitis severity and systemic inflammation: An experimental study

Gabriel J. Seifert et al.

ANNALS OF MEDICINE AND SURGERY (2017)

Article Oncology

IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia

Yuliya Pylayeva-Gupta et al.

CANCER DISCOVERY (2016)

Article Oncology

Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer

Andrew J. Gunderson et al.

CANCER DISCOVERY (2016)

Article Endocrinology & Metabolism

Insulin resistance is associated with the aggressiveness of pancreatic ductal carcinoma

Erica Dugnani et al.

ACTA DIABETOLOGICA (2016)

Review Medicine, General & Internal

Role of immune cells in pancreatic cancer from bench to clinical application An updated review

Jae Hyuck Chang et al.

MEDICINE (2016)

Article Medicine, General & Internal

Body Fatness and Cancer - Viewpoint of the IARC Working Group

Beatrice Lauby-Secretan et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Biochemistry & Molecular Biology

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

Maxim V. Kuleshov et al.

NUCLEIC ACIDS RESEARCH (2016)

Review Gastroenterology & Hepatology

Epidemiology of pancreatic cancer

Milena Ilic et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

Article Medicine, General & Internal

Pancreatic Ductal Adenocarcinoma

Megan B. Wachsmann et al.

JOURNAL OF INVESTIGATIVE MEDICINE (2016)

Article Endocrinology & Metabolism

Suppression of hyperinsulinaemia in growing female mice provides long-term protection against obesity

Nicole M. Templeman et al.

DIABETOLOGIA (2015)

Article Gastroenterology & Hepatology

Reg3g Promotes Pancreatic Carcinogenesis in a Murine Model of Chronic Pancreatitis

Guoxiao Yin et al.

DIGESTIVE DISEASES AND SCIENCES (2015)

Review Physiology

OBESITY AND DIABETES: THE INCREASED RISK OF CANCER AND CANCER-RELATED MORTALITY

Emily Jane Gallagher et al.

PHYSIOLOGICAL REVIEWS (2015)

Review Immunology

Control of macrophage metabolism and activation by mTOR and Akt signaling

Anthony J. Covarrubias et al.

SEMINARS IN IMMUNOLOGY (2015)

Review Endocrinology & Metabolism

Sex differences in metabolic homeostasis, diabetes, and obesity

Franck Mauvais-Jarvis

BIOLOGY OF SEX DIFFERENCES (2015)

Article Oncology

CD4+ T Lymphocyte Ablation Prevents Pancreatic Carcinogenesis in Mice

Yaqing Zhang et al.

CANCER IMMUNOLOGY RESEARCH (2014)

Article Endocrinology & Metabolism

Insulin resistance/hyperinsulinemia and cancer mortality: the Cremona study at the 15th year of follow-up

Gianluca Perseghin et al.

ACTA DIABETOLOGICA (2012)

Review Endocrinology & Metabolism

Insulin Resistance and Cancer Risk: An Overview of the Pathogenetic Mechanisms

Biagio Arcidiacono et al.

EXPERIMENTAL DIABETES RESEARCH (2012)

Editorial Material Gastroenterology & Hepatology

Which Way to Die: the Regulation of Acinar Cell Death in Pancreatitis by Mitochondria, Calcium, and Reactive Oxygen Species

Anna S. Gukovskaya et al.

GASTROENTEROLOGY (2011)

Review Biochemistry & Molecular Biology

Multi-layered regulation of intestinal antimicrobial defense

S. Mukherjee et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2008)

Review Gastroenterology & Hepatology

Pancreatic cancer: A review of the evidence on causation

Andrew R. Hart et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2008)

Review Gastroenterology & Hepatology

Pancreatic carcinogenesis

Jan-Bart M. Koorstra et al.

PANCREATOLOGY (2008)

Article Endocrinology & Metabolism

Hyper-insulinaemia and cancer, meta-analyses of epidemiological studies

Paola Pisani

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2008)

Article Gastroenterology & Hepatology

Basic-liver, pancreas, and biliary tract

Oliver Strobel et al.

GASTROENTEROLOGY (2007)

Review Endocrinology & Metabolism

Comparative analysis of insulin gene promoters - Implications for diabetes research

Colin W. Hay et al.

DIABETES (2006)

Article Medicine, General & Internal

Insulin, glucose, insulin resistance, and pancreatic cancer in male smokers

RZ Stolzenberg-Solomon et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2005)

Article Biochemistry & Molecular Biology

Risk factors for pancreatic cancer

AB Lowenfels et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2005)

Review Endocrinology & Metabolism

Diabetes and gender

EAM Gale et al.

DIABETOLOGIA (2001)