4.6 Article

α-Synuclein aggregation in the olfactory bulb induces olfactory deficits by perturbing granule cells and granular-mitral synaptic transmission

Related references

Note: Only part of the references are listed.
Article Physiology

Oxytocin modulates neural processing of mitral/tufted cells in the olfactory bulb

Changcheng Sun et al.

Summary: Direct infusion of oxytocin into the olfactory bulb enhances social interaction performance in mice and increases odour-evoked responses of mitral/tufted cells while reducing their spontaneous firing rate. Oxytocin modulates neural activity in the olfactory bulb by decreasing odour-evoked high gamma responses and calcium responses in granule cells, potentially through ATP-sensitive potassium channels.

ACTA PHYSIOLOGICA (2021)

Article Geriatrics & Gerontology

GABAA receptor agonist muscimol rescues inhibitory microcircuit defects in the olfactory bulb and improves olfactory function in APP/PS1 transgenic mice

Bin Hu et al.

Summary: Olfactory damage occurs early in Alzheimer's disease, potentially related to impaired inhibitory transmission. Experimental evidence suggests that deficits in presynaptic GABAergic transmission may contribute to olfactory dysfunction and the progression of AD.

NEUROBIOLOGY OF AGING (2021)

Article Neurosciences

α-Synuclein Promotes Maturation of Immature Juxtaglomerular Neurons in the Mouse Olfactory Bulb

Katsutoshi Taguchi et al.

MOLECULAR NEUROBIOLOGY (2020)

Article Neurosciences

Perturbation of in vivo Neural Activity Following alpha-Synuclein Seeding in the Olfactory Bulb

Aishwarya S. Kulkarni et al.

JOURNAL OF PARKINSONS DISEASE (2020)

Article Biochemistry & Molecular Biology

The A30P α-synuclein mutation decreases subventricular zone proliferation

Xue-Ming Zhang et al.

HUMAN MOLECULAR GENETICS (2019)

Article Multidisciplinary Sciences

α-Synuclein oligomers mediate the aberrant form of spike-induced calcium release from IP3 receptor

Kenji Yamamoto et al.

SCIENTIFIC REPORTS (2019)

Article Neurosciences

The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases

Nolwen L. Rey et al.

NEUROBIOLOGY OF DISEASE (2018)

Article Clinical Neurology

Distinctive Olfactory Pattern in Parkinson's Disease and Non-Neurodegenerative Causes of Hyposmia

Ane Miren Crespo Cuevas et al.

NEURODEGENERATIVE DISEASES (2018)

Article Multidisciplinary Sciences

α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies

Iryna Prots et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease

Marthe H. R. Ludtmann et al.

NATURE COMMUNICATIONS (2018)

Article Neurosciences

Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning

Nagendran Muthusamy et al.

NATURE NEUROSCIENCE (2017)

Article Neurosciences

Cilia- and Flagella-Associated Protein 69 Regulates Olfactory Transduction Kinetics in Mice

Anna K. Talaga et al.

JOURNAL OF NEUROSCIENCE (2017)

Review Neurosciences

Olfactory Dysfunction as an Early Biomarker in Parkinson's Disease

Michelle E. Fullard et al.

NEUROSCIENCE BULLETIN (2017)

Review Neurosciences

Neuromodulation of olfactory transformations

Christiane Linster et al.

CURRENT OPINION IN NEUROBIOLOGY (2016)

Article Neurosciences

Diverse Representations of Olfactory Information in Centrifugal Feedback Projections

Krishnan Padmanabhan et al.

JOURNAL OF NEUROSCIENCE (2016)

Article Neurosciences

Parallel processing of afferent olfactory sensory information

Christopher E. Vaaga et al.

JOURNAL OF PHYSIOLOGY-LONDON (2016)

Article Multidisciplinary Sciences

Combinatorial effects of odorants on mouse behavior

Luis R. Saraiva et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Clinical Neurology

A new dopaminergic nigro-olfactory projection

Guenter U. Hoeglinger et al.

ACTA NEUROPATHOLOGICA (2015)

Article Multidisciplinary Sciences

A computational perspective on autism

Ari Rosenberg et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Neurosciences

Unilateral olfactory deficit in a hemiparkinson's disease mouse model

Pablo Valle-Leija et al.

NEUROREPORT (2014)

Article Multidisciplinary Sciences

A30P α-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network

Johanna Neuner et al.

SCIENTIFIC REPORTS (2014)

Article Multidisciplinary Sciences

Rasagiline Ameliorates Olfactory Deficits in an Alpha-Synuclein Mouse Model of Parkinson's Disease

Geraldine H. Petit et al.

PLOS ONE (2013)

Article Biochemistry & Molecular Biology

α-Synuclein accumulation reduces GABAergic inhibitory transmission in a model of multiple system atrophy

Hiroshi Ito et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)

Review Clinical Neurology

Olfactory dysfunction in Parkinson disease

Richard L. Doty

NATURE REVIEWS NEUROLOGY (2012)

Article Neurosciences

Associative Cortex Features in the First Olfactory Brain Relay Station

Wilder Doucette et al.

NEURON (2011)

Article Neurosciences

A Pathologic Cascade Leading to Synaptic Dysfunction in α-Synuclein-Induced Neurodegeneration

David A. Scott et al.

JOURNAL OF NEUROSCIENCE (2010)

Article Neurosciences

Neural correlates of olfactory learning: Critical role of centrifugal neuromodulation

Max L. Fletcher et al.

LEARNING & MEMORY (2010)

Article Neurosciences

Olfactory deficits in mice overexpressing human wildtype α-synuclein

Sheila M. Fleming et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2008)

Article Multidisciplinary Sciences

Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease

Marc Aurel Busche et al.

SCIENCE (2008)

Article Multidisciplinary Sciences

Innate versus learned odour processing in the mouse olfactory bulb

Ko Kobayakawa et al.

NATURE (2007)

Article Neurosciences

Different species of α-synuclein oligomers induce calcium influx and seeding

Karin M. Danzer et al.

JOURNAL OF NEUROSCIENCE (2007)

Article Biochemistry & Molecular Biology

The impact of the E46K mutation on the properties of α-synuclein in its monomeric and oligomeric states

Ross A. Fredenburg et al.

BIOCHEMISTRY (2007)

Review Cell Biology

Stages in the development of Parkinson's disease-related pathology

H Braak et al.

CELL AND TISSUE RESEARCH (2004)

Article Biochemistry & Molecular Biology

The role of alpha-synuclein assembly and metabolism in the pathogenesis of Lewy body disease

M Hashimoto et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2004)

Article Pathology

α-synuclein promotes mitochondrial deficit and oxidative stress

LJ Hsu et al.

AMERICAN JOURNAL OF PATHOLOGY (2000)