Journal
MATERIALS CHEMISTRY FRONTIERS
Volume 6, Issue 5, Pages 553-560Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1qm01665b
Keywords
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education [2021R1A6A1A10039823, 2019R1A5A2026045]
- Korea Basic Science Institute (National Research Facilities and Equipment Centre) - Ministry of Education [2019R1A6C1010003]
- National Research Foundation of Korea [2019R1A6C1010003] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The study presents a new fluorogenic probe for detecting dynamic changes and aberrant polarity of lipid droplets, which could potentially be beneficial for clinical diagnosis and tracking the origin of lipid droplets and monitoring polarity-related subcellular organelles.
The key mechanism of lipid droplet-related diseases and polarity remains undetermined due to a scarcity of research on numerous condition models. We developed a conventional donor-acceptor fluorogenic probe with the untwisted intramolecular charge process. It is near-infrared-excited two-photon LD-specific and polarity-sensitive. This probe can detect dynamic changes of LD polarity in cancer cells and visualizes aberrant LD polarity in hepatic steatosis models. In the future, it could be beneficial for clinical diagnosis of LD polarity-related symptoms and to track the origin of lipid droplets and to monitor polarity-relative subcellular organelles.
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