4.6 Article

Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn

Journal

NPJ REGENERATIVE MEDICINE
Volume 6, Issue 1, Pages -

Publisher

NATURE PORTFOLIO
DOI: 10.1038/s41536-021-00185-5

Keywords

-

Funding

  1. ARC DECRA Fellowship [DE180100984]
  2. Australian Government
  3. NHMRC - Australian Government [APP1125290]
  4. Royal Brisbane and Women's Hospital Research Grant
  5. Financial Markets Foundation for Children [2018-043]
  6. UQ Early Career Researcher grant
  7. Australian Research Council [DE180100984] Funding Source: Australian Research Council

Ask authors/readers for more resources

The study found that a dose of combined MSC-ECFC on the first day of life for FGR newborn piglets improved damaged vasculature, restored the neurovascular unit, reduced brain inflammation, and improved adverse neuronal and white matter changes in the FGR newborn piglet brain. These effects were not observed with MSCs alone, indicating that cECFC treatment may act as a neuroprotectant for the FGR brain.
The foetal brain is particularly vulnerable to the detrimental effects of foetal growth restriction (FGR) with subsequent abnormal neurodevelopment being common. There are no current treatments to protect the FGR newborn from lifelong neurological disorders. This study examines whether pure foetal mesenchymal stromal cells (MSC) and endothelial colony-forming cells (ECFC) from the human term placenta are neuroprotective through modulating neuroinflammation and supporting the brain vasculature. We determined that one dose of combined MSC-ECFCs (cECFC; 10(6) ECFC 10(6) MSC) on the first day of life to the newborn FGR piglet improved damaged vasculature, restored the neurovascular unit, reduced brain inflammation and improved adverse neuronal and white matter changes present in the FGR newborn piglet brain. These findings could not be reproduced using MSCs alone. These results demonstrate cECFC treatment exerts beneficial effects on multiple cellular components in the FGR brain and may act as a neuroprotectant.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available