Journal
NEUROBIOLOGY OF STRESS
Volume 15, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ynstr.2021.100405
Keywords
Zebrafish; Rodents; Cortisol; Stress axis; Behavior; Animal models
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Funding
- Zebrafish Platform Construction Fund from the Southwest University (Chongqing, China)
- Russian Science Foundation (RSF) [19-15-00053]
- President of Russia Graduate Fellowship
- Special Rector's Fellowship for SPSU students
- FAPERGS [19/2551-0001-669-7]
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Studying the mechanisms of stress response and modeling related disorders has always been an important topic. Aquatic animal models, particularly zebrafish, have played a crucial role in this area. This article focuses on the evolution of stress responses from zebrafish to rodents and humans, as well as discusses its implications in translational medicine.
Stress response is essential for the organism to quickly restore physiological homeostasis disturbed by various environmental insults. In addition to well-established physiological cascades, stress also evokes various brain and behavioral responses. Aquatic animal models, including the zebrafish (Danio rerio), have been extensively used to probe pathobiological mechanisms of stress and stress-related brain disorders. Here, we critically discuss the use of zebrafish models for studying mechanisms of stress and modeling its disorders experimentally, with a particular cross-taxon focus on the potential evolution of stress responses from zebrafish to rodents and humans, as well as its translational implications.
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