Journal
BIOACTIVE MATERIALS
Volume 15, Issue -, Pages 82-102Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2021.12.005
Keywords
Substrate stiffness; Cellular response; Cell-matrix interaction; Mechanobiology; Tissue engineering
Funding
- Fundamental Research Funds for Na-tional Key Research and Development Program of China [2018YFC1105800]
- China Postdoctoral Science Foundation [2020M681322]
- National Natural Science Foundation of China [31870967, 81671921]
Ask authors/readers for more resources
Cell-matrix interactions and substrate stiffness play critical roles in tissue repair and regeneration. This review provides an overview of recent progress in understanding the cellular responses mediated by substrate stiffness and the manipulation of scaffold stiffness. It aims to facilitate interdisciplinary knowledge transfer and the design of suitable biomaterials for tissue regeneration.
Cell-matrix interactions play a critical role in tissue repair and regeneration. With gradual uncovering of substrate mechanical characteristics that can affect cell-matrix interactions, much progress has been made to unravel substrate stiffness-mediated cellular response as well as its underlying mechanisms. Yet, as a part of cell-matrix interaction biology, this field remains in its infancy, and the detailed molecular mechanisms are still elusive regarding scaffold-modulated tissue regeneration. This review provides an overview of recent progress in the area of the substrate stiffness-mediated cellular responses, including 1) the physical determination of substrate stiffness on cell fate and tissue development; 2) the current exploited approaches to manipulate the stiffness of scaffolds; 3) the progress of recent researches to reveal the role of substrate stiffness in cellular responses in some representative tissue-engineered regeneration varying from stiff tissue to soft tissue. This article aims to provide an up-to-date overview of cell mechanobiology research in substrate stiffness mediated cellular response and tissue regeneration with insightful information to facilitate interdisciplinary knowledge transfer and enable the establishment of prognostic markers for the design of suitable biomaterials.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available