Biomaterial strategies for the application of reproductive tissue engineering

Human reproductive organs are of vital importance to the life of an individual and the reproduction of human populations. So far, traditional methods have a limited effect in recovering the function and fertility of reproductive organs and tissues. Thus, aim to replace and facilitate the regrowth of damaged or diseased tissue, various biomaterials are developed to offer hope to overcome these difficulties and help gain further research progress in reproductive tissue engineering. In this review, we focus on the biomaterials and their four main applications in reproductive tissue engineering: in vitro generation and culture of reproductive cells; development of reproductive organoids and models; in vivo transplantation of reproductive cells or tissues; and regeneration of reproductive tissue. In reproductive tissue engineering, designing biomaterials for different applications with different mechanical properties, structure, function, and microenvironment is challenging and important, and deserves more attention.

Automated summary

Human reproductive organs are crucial for individual life and human reproduction. Traditional methods have limited effects on restoring organ function and fertility. Biomaterials offer hope for overcoming these difficulties and advancing research in reproductive tissue engineering. This review focuses on the applications of biomaterials in vitro generation and culture, organoid and model development, in vivo transplantation, and tissue regeneration. Designing biomaterials with different properties and microenvironments is challenging and important.