Journal
BIOACTIVE MATERIALS
Volume 6, Issue 11, Pages 3865-3878Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2021.04.004
Keywords
Leukocyte/platelet hybrid membrane; Dendritic large pore mesoporous silica nanoparticles; Triple-negative breast cancer; Phototherapy; Chemotherapy
Funding
- National Natural Science Foundation of China [81972903, 12074284, 81803101]
- Natural Science Foundation of Tianjin City of China [18JCZDJC33400, 19JCQNJC12300]
- Excellent Talent Project of Tianjin Medical University
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A biomimetic nanoplatform was developed for efficient co-loading and targeted delivery of photo/chemotherapeutic agents for TNBC combination treatment, showing excellent TNBC-targeting ability and high PTT/PDT performances both in vitro and in vivo. This platform exhibited synergistic cytotoxicity and apoptosis-inducing activity in TNBC cells, effectively suppressing tumor growth and recurrence through tumor ablation and antiangiogenesis.
Triple-negative breast cancer (TNBC) is an aggressive subset of breast cancer and currently lacks effective therapeutic targets. As two main phototherapeutic methods, photothermal therapy (PTT) and photodynamic therapy (PDT) show many advantages in TNBC treatment, and their combination with chemotherapy can achieve synergistic therapeutic effects. In the present study, a biomimetic nanoplatform was developed based on leukocyte/platelet hybrid membrane (LPHM) and dendritic large pore mesoporous silicon nanoparticles (DLMSNs). A near infrared (NIR) fluorescent dye IR780 and a chemotherapeutic drug doxorubicin (DOX) were co-loaded into the large pores of DLMSNs to prepare DLMSN@DOX/IR780 (DDI) nanoparticles (NPs), followed by camouflage with LPHM to obtain LPHM@DDI NPs. Through the mediation of LPHM, LPHM@DDI NPs showed an excellent TNBC-targeting ability and very high PTT/PDT performances in vitro and in vivo. Upon NIR laser irradiation, LPHM@DDI NPs exhibited synergistic cytotoxicity and apoptosis-inducing activity in TNBC cells, and effectively suppressed tumor growth and recurrence in TNBC mice through tumor ablation and antiangiogenesis. These synergistic effects were sourced from the combination of PTT/PDT and chemotherapy. Altogether, this study offers a promising biomimetic nanoplatform for efficient co-loading and targeted delivery of photo/chemotherapeutic agents for TNBC combination treatment.
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