Journal
BIOACTIVE MATERIALS
Volume 18, Issue -, Pages 15-25Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2022.01.048
Keywords
Bone organoid; Bone regeneration; Scaffold; Disease models
Funding
- National Key Research and Development Plan [2018YFC2001500]
- National Natural Science Foundation of China [82172098, 81972254, 81871099, 32101084]
- Shanghai Rising-Star Program [21QA1412000]
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The repair and regeneration of bone defects caused by various factors have always been a key issue in clinical practice. Bone tissue engineering technology has greatly accelerated the speed and quality of bone regeneration by providing functional scaffold materials and seed cells. However, the complicated bone metabolism mechanism poses challenges to research in bone regeneration. Organoids, as a new concept, show promising application prospects in organ development, drug screening, and mechanism study.
Bone defects repair and regeneration by various causes such as tumor resection, trauma, degeneration, etc. have always been a key issue in the clinics. As one of the few organs that can regenerate after adulthood, bone itself has a strong regenerative ability. In recent decades, bone tissue engineering technology provides various types of functional scaffold materials and seed cells for bone regeneration and repair, which significantly accelerates the speed and quality of bone regeneration, and many clinical problems are gradually solved. However, the bone metabolism mechanism is complicated, the research duration is long and difficult, which significantly restricts the progress of bone regeneration and repair research. Organoids as a new concept, which is built in vitro with the help of tissue engineering technology based on biological theory, can simulate the complex biological functions of organs in vivo. Once proposed, it shows broad application prospects in the research of organ development, drug screening, mechanism study, and so on. As a complex and special organ, bone organoid construction itself is quite challenging. This review will introduce the characteristics of bone microenvironment, the concept of organoids, focus on the research progress of bone organoids, and propose the strategies for bone organoid construction, study direction, and application prospects.
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