Journal
BIOACTIVE MATERIALS
Volume 8, Issue -, Pages 559-572Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2021.06.028
Keywords
Coaxial nanofiber; Baicalin; Inflammation; Osteoclast differentiation; Vascularized bone regeneration
Funding
- National Key Research and Development Program of China [2016YFA0201703/2016YFA0201700]
- Key R&D Project of Sichuan Science and Technology Plan [2021YFS0030]
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We demonstrate a simple and feasible method to address the shrinkage of PLGA fibers through a core-shell structure strategy. The modified fibrous scaffold shows potential in promoting osteogenic differentiation and neovascularization for vascularized bone regeneration.
We demonstrate a simple, effective and feasible method to address the shrinkage of Poly (lactic-co-glycolic acid) (PLGA) through a core-shell structure fiber strategy. The results revealed that introducing size-stable poly-caprolactone (PCL) as the core fiber significantly improved the PLGA-based fibrous scaffold's dimensional maintenance. We further utilized fish collagen to modify the PLGA shell layer (PFC) of coaxial fibers and loaded baicalin (BA) into the PCL core layer (PCL-BA) to endow fibrous scaffold with more functional biological cues. The PFC/PCL-BA fibrous scaffold promoted the osteogenic differentiation of bone mesenchymal stem cells and stimulated the RAW264.7 cells to polarize into a pro-reparative phenotype. Importantly, the in vivo study demonstrated that the PFC/PCL-BA scaffold could regulate inflammation and osteoclast differentiation, favor neovascularization and bone formation. This work tactfully combined PLGA and PCL to establish a drug release platform based on the core-shell fibrous scaffold for vascularized bone regeneration.
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