Journal
BIOACTIVE MATERIALS
Volume 18, Issue -, Pages 56-71Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2022.02.006
Keywords
Mesenchymal stem cell recruitment; Osteogenic differentiation; Hydroxyapatite; Titanium; Osteoporosis
Funding
- National Natural Science Foundation of China [51773023, 21734002, 51825302]
- National Key R&D Program of China [2017YFB0702603]
- Graduate Research and Innovation Foundation of Chongqing [CYB20071]
- Natural Science Foundation of Chongqing Municipal Government [cstc2018jcyjAX0368, cstc2020jcyj-msxmX0834, CX2018062]
- Chongqing Outstanding Young Talent Sup-porting Program [CQYC201905072]
- Fundamental Research Funds for the Central Universities [2019CDQYSW005, 2020CDJQY-A075, 2020CDJYGZL009]
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By fabricating a ROS-responsive system on titanium surface, MSC recruitment and osteogenic differentiation can be enhanced, providing a potential treatment for osteoporotic fractures.
To solve the issue of unsatisfactory recruitment of mesenchymal stem cells (MSCs) around implant in osteoporotic fractures, we fabricated a ROS-responsive system on titanium surface through hydroxyapatite coating and biomolecule grafting. The porous hydroxyapatite and phosphorylated osteogenic growth peptides (p-OGP) were introduced onto titanium surface to synergistically improve osteogenic differentiation of MSCs. After the p-OGP-promoted expression of osteogenic related proteins, the calcium and phosphate ions were released through the degradation of hydroxyapatite and integrated into bone tissues to boost the mineralization of bone matrix. The ROS-triggered release of DNA aptamer (Apt) 19S in the osteoporotic microenvironment guides MSC migration to implant site due to its high affinity with alkaline phosphatase on the membrane of MSCs. Once MSCs reached the implant interface, their osteogenic differentiation potential was enhanced by p-OGP and hydroxyapatite to promote bone regeneration. The study here provided a simple and novel strategy to prepare functional titanium implants for osteoporotic bone fracture repair.
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